Version 5.4
Bos taurus Gene: LPHN1
Summary
InnateDB Gene IDBG-642699.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LPHN1
Gene Name Latrophilin-1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000003675
Encoded Proteins
IDBP-695207
latrophilin-1 precursor
IDBP-695209
latrophilin-1 precursor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000072071:
This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:12610668-12658973
Strand Forward strand
Band
Transcripts
ENSBTAT00000036251 ENSBTAP00000036113
ENSBTAT00000004789 ENSBTAP00000004789
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0005515 protein binding
GO:0016524 latrotoxin receptor activity
GO:0030246 carbohydrate binding
GO:0050839 cell adhesion molecule binding
Biological Process
GO:0007157 heterophilic cell-cell adhesion
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
GO:0035584 calcium-mediated signaling using intracellular calcium source
GO:0090129 positive regulation of synapse maturation
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0030424 axon
GO:0030426 growth cone
GO:0042734 presynaptic membrane
GO:0042995 cell projection
GO:0043005 neuron projection
GO:0045202 synapse
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000072071
View Gene Order
ENSMUSG00000013033
View Gene Order
Cross-References
SwissProt O97831
TrEMBL A6QLH0 F1MEV6
UniProt Splice Variant
Entrez Gene 788252
UniGene Bt.27855
RefSeq NM_001113728 XM_005208626
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF111097 AF111098 BC147961 DAAA02019342 DAAA02019343 DAAA02019344 DAAA02019345
GenPept AAD09191 AAD09192 AAI47962
RNA Seq Atlas 788252

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca