InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PDCD1

Summary

InnateDB Gene

IDBG-642702.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDCD1

Gene Name

programmed cell death protein 1 precursor

Synonyms

PD-1

Species

Bos taurus

Ensembl Gene

ENSBTAG00000011543

Encoded Proteins

IDBP-695185

programmed cell death protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 21091911

[Homo sapiens] PDCD1 mediates functional impairment of early immune responses during HCV infection by limiting STAT1 phosphorylation, which consequently inhibits IL12 expression in monocytes / macrophages.

PMID 21263073

[Homo sapiens] PDCD1 expression in T cells is induced by IFNA stimulation and provides feedback inhibition of T cell activation. It is proposed that strong innate inflammatory response (i.e. IFNA secretion) cause an attenuated T cell response by PDCD1 in sustained immune reaction.

PMID 21263070

[Homo sapiens] PDCD1 is a negative immunomodulator that is upregulated by Hepatitis C virus to deliver negative signaling to TLR-mediated pathways controlling expression of IL12, a key cytokine linking innate and adaptive immunity.

PMID 21263073

[Mus musculus] Pdcd1 expression in T cells is induced by Ifna stimulation and provides feedback inhibition of T cell activation. It is proposed that strong innate inflammatory response (i.e. Ifna secretion) cause an attenuated T cell response by Pdcd1 in sustained immune reaction.

PMID 21263070

[Mus musculus] Pdcd1 is a negative immunomodulator that is upregulated by Hepatitis C virus to deliver negative signaling to Tlr-mediated pathways controlling expression of Il12, a key cytokine linking innate and adaptive immunity.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000188389:
This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq, Jul 2008]
This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:121284545-121294475

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000015337

ENSBTAP00000015337

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.