Version 5.4
Homo sapiens Gene: PDCD1
Summary
InnateDB Gene IDBG-85346.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PDCD1
Gene Name programmed cell death 1
Synonyms CD279; hPD-1; hPD-l; hSLE1; PD-1; PD1; SLEB2
Species Homo sapiens
Ensembl Gene ENSG00000188389
Encoded Proteins
IDBP-85348
programmed cell death 1
IDBP-85350
programmed cell death 1
IDBP-389744
programmed cell death 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21091911
PDCD1 mediates functional impairment of early immune responses during HCV infection by limiting STAT1 phosphorylation, which consequently inhibits IL12 expression in monocytes / macrophages.
PMID 21263073
PDCD1 expression in T cells is induced by IFNA stimulation and provides feedback inhibition of T cell activation. It is proposed that strong innate inflammatory response (i.e. IFNA secretion) cause an attenuated T cell response by PDCD1 in sustained immune reaction.
PMID 21263070
PDCD1 is a negative immunomodulator that is upregulated by Hepatitis C virus to deliver negative signaling to TLR-mediated pathways controlling expression of IL12, a key cytokine linking innate and adaptive immunity.
InnateDB Annotation from Orthologs
Summary
PMID 21263073
[Mus musculus] Pdcd1 expression in T cells is induced by Ifna stimulation and provides feedback inhibition of T cell activation. It is proposed that strong innate inflammatory response (i.e. Ifna secretion) cause an attenuated T cell response by Pdcd1 in sustained immune reaction.
PMID 21263070
[Mus musculus] Pdcd1 is a negative immunomodulator that is upregulated by Hepatitis C virus to deliver negative signaling to Tlr-mediated pathways controlling expression of Il12, a key cytokine linking innate and adaptive immunity.
Entrez Gene
Summary This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq, Jul 2008]
This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:241849881-241858908
Strand Reverse strand
Band q37.3
Transcripts
ENST00000334409 ENSP00000335062
ENST00000343705 ENSP00000340808
ENST00000418831 ENSP00000390296
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005515 protein binding
Biological Process
GO:0006915 apoptotic process
GO:0006959 humoral immune response
GO:0007165 signal transduction
GO:0007275 multicellular organismal development
GO:0031295 T cell costimulation
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026285
View Gene Order
ENSBTAG00000011543
Not yet available
Pathways
NETPATH
REACTOME
REACT_19324
PD-1 signaling pathway
REACT_19344
Costimulation by the CD28 family pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
KEGG
hsa04514
Cell adhesion molecules (CAMs) pathway
hsa04660
T cell receptor signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.158297
RefSeq NM_005018
HUGO
OMIM
CCDS CCDS33428
HPRD 02590
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca