Version 5.4
Bos taurus Gene: ACR
Summary
InnateDB Gene IDBG-642845.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ACR
Gene Name acrosin precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000010182
Encoded Proteins
IDBP-695343
acrosin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100312:
Acrosin is the major proteinase present in the acrosome of mature spermatozoa. It is a typical serine proteinase with trypsin-like specificity. It is stored in the acrosome in its precursor form, proacrosin. The active enzyme functions in the lysis of the zona pellucida, thus facilitating penetration of the sperm through the innermost glycoprotein layers of the ovum. The mRNA for proacrosin is synthesized only in the postmeiotic stages of spermatogenesis. In humans proacrosin first appears in the haploid spermatids. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:120222129-120229501
Strand Forward strand
Band
Transcripts
ENSBTAT00000013434 ENSBTAP00000013434
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
GO:0005537 mannose binding
GO:0008233 peptidase activity
GO:0008236 serine-type peptidase activity
GO:0016787 hydrolase activity
Biological Process
GO:0006508 proteolysis
GO:0007190 activation of adenylate cyclase activity
GO:0007338 single fertilization
GO:0007339 binding of sperm to zona pellucida
GO:0007340 acrosome reaction
GO:0007341 penetration of zona pellucida
Cellular Component
GO:0001669 acrosomal vesicle
GO:0005634 nucleus
GO:0043234 protein complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000100312
View Gene Order
ENSMUSG00000022622
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_163938
Acrosome Reaction pathway
REACT_163914
Fertilization pathway
REACT_163848
Reproduction pathway
REACT_199082
Fertilization pathway
REACT_199085
Reproduction pathway
REACT_199073
Acrosome Reaction pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL G5E5C6
UniProt Splice Variant
Entrez Gene 280711
UniGene Bt.45050
RefSeq NM_173886 XM_005207499
HUGO HGNC:126
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02015066 DAAA02015067
GenPept
RNA Seq Atlas 280711

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca