InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Acr

Summary

InnateDB Gene

IDBG-174668.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Acr

Gene Name

acrosin prepropeptide

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000022622

Encoded Proteins

IDBP-174670

acrosin prepropeptide

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100312:
Acrosin is the major proteinase present in the acrosome of mature spermatozoa. It is a typical serine proteinase with trypsin-like specificity. It is stored in the acrosome in its precursor form, proacrosin. The active enzyme functions in the lysis of the zona pellucida, thus facilitating penetration of the sperm through the innermost glycoprotein layers of the ovum. The mRNA for proacrosin is synthesized only in the postmeiotic stages of spermatogenesis. In humans proacrosin first appears in the haploid spermatids. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:89568326-89574585

Strand

Forward strand

Band

Transcripts

ENSMUST00000023295

ENSMUSP00000023295

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004040	amidase activity
GO:0004252	serine-type endopeptidase activity
GO:0005515	protein binding
GO:0005537	mannose binding
GO:0008144	drug binding
GO:0008233	peptidase activity
GO:0042806	fucose binding

Biological Process

GO:0006508	proteolysis
GO:0007190	activation of adenylate cyclase activity
GO:0007338	single fertilization
GO:0007339	binding of sperm to zona pellucida
GO:0007340	acrosome reaction
GO:0007341	penetration of zona pellucida
GO:0048545	response to steroid hormone

Cellular Component

GO:0001669	acrosomal vesicle
GO:0005634	nucleus
GO:0005798	Golgi-associated vesicle
GO:0043159	acrosomal matrix
GO:0043234	protein complex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000100312

View Gene Order

ENSBTAG00000010182

Not yet available

Pathways

NETPATH

REACTOME

REACT_199082

Fertilization pathway

REACT_199085

Reproduction pathway

REACT_199073

Acrosome Reaction pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_163938

Acrosome Reaction pathway

REACT_163914

Fertilization pathway

REACT_163848

Reproduction pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

P23578

TrEMBL

Q3ZB05 Q3ZB06

UniProt Splice Variant

Entrez Gene

11434

UniGene

Mm.57

RefSeq

NM_001205049 NM_001277245 NM_001277246 NM_001277247 NM_013455

OMIM

CCDS

CCDS27755

HPRD

IMGT

MGI ID

MGI:87884

MGI Symbol

Acr

EMBL

BC103577 BC103578 BC103579 D00754 M85170 M96426 M96427 M96428 M96430 S64500 S66243 S66245 X52466

GenPept

AAA37163 AAA40124 AAB20293 AAI03578 AAI03579 AAI03580 BAA00651 CAA36704

RNA Seq Atlas

11434