InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: STK4

Summary

InnateDB Gene

IDBG-642847.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STK4

Gene Name

Serine/threonine-protein kinase 4 Serine/threonine-protein kinase 4 37kDa subunit Serine/threonine-protein kinase 4 18kDa subunit

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000003257

Encoded Proteins

IDBP-695344

Serine/threonine-protein kinase 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101109:
The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it\'s possible that this protein induces the chromatin condensation observed in this process. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:74092649-74179111

Strand

Forward strand

Band

Transcripts

ENSBTAT00000004221

ENSBTAP00000004221

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.

Predicted by orthology
Total	36 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008134	transcription factor binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding
GO:0046983	protein dimerization activity

Biological Process

GO:0000902	cell morphogenesis
GO:0001569	patterning of blood vessels
GO:0001841	neural tube formation
GO:0003157	endocardium development
GO:0006468	protein phosphorylation
GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0007417	central nervous system development
GO:0008285	negative regulation of cell proliferation
GO:0016310	phosphorylation
GO:0018105	peptidyl-serine phosphorylation
GO:0023014	signal transduction by phosphorylation
GO:0030216	keratinocyte differentiation
GO:0035329	hippo signaling
GO:0035556	intracellular signal transduction
GO:0043065	positive regulation of apoptotic process
GO:0046621	negative regulation of organ growth
GO:0046777	protein autophosphorylation
GO:0060215	primitive hemopoiesis
GO:0060706	cell differentiation involved in embryonic placenta development
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:0097284	hepatocyte apoptotic process
GO:1902043	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors