Version 5.4
Homo sapiens Gene: AACS
Summary
InnateDB Gene IDBG-64292.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AACS
Gene Name acetoacetyl-CoA synthetase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000081760
Encoded Proteins
IDBP-64296
acetoacetyl-CoA synthetase
IDBP-385057
acetoacetyl-CoA synthetase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 12:125065379-125143333
Strand Forward strand
Band q24.31
Transcripts
ENST00000316519 ENSP00000324842
ENST00000316543
ENST00000398953
ENST00000441247
ENST00000418937 ENSP00000416461
ENST00000537477
ENST00000537564
ENST00000539251
ENST00000538851
ENST00000545511
ENST00000536118
ENST00000543665
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0005524 ATP binding
GO:0030729 acetoacetate-CoA ligase activity
GO:0047760 butyrate-CoA ligase activity
Biological Process
GO:0001889 liver development
GO:0006629 lipid metabolic process
GO:0006631 fatty acid metabolic process
GO:0007584 response to nutrient
GO:0008152 metabolic process
GO:0010243 response to organonitrogen compound
GO:0014070 response to organic cyclic compound
GO:0014074 response to purine-containing compound
GO:0032024 positive regulation of insulin secretion
GO:0034201 response to oleic acid
GO:0042493 response to drug
GO:0042594 response to starvation
GO:0045471 response to ethanol
GO:0050872 white fat cell differentiation
GO:0060612 adipose tissue development
GO:0071333 cellular response to glucose stimulus
GO:0071394 cellular response to testosterone stimulus
GO:0071397 cellular response to cholesterol
Cellular Component
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029482
View Gene Order
ENSBTAG00000005678
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00650
Butanoate metabolism pathway
INOH
INOH website
Butanoate metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL E7EW25 F5H790
UniProt Splice Variant
Entrez Gene 65985
UniGene Hs.642258 Hs.656073
RefSeq NM_023928
HUGO HGNC:21298
OMIM 614364
CCDS CCDS9263
HPRD 12391
IMGT
EMBL AC122688
GenPept
RNA Seq Atlas 65985

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca