Version 5.4
Homo sapiens Protein: AACS
Summary
InnateDB Protein IDBP-64296.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AACS
Protein Name acetoacetyl-CoA synthetase
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000324842
InnateDB Gene IDBG-64292 (AACS)
Protein Structure
UniProt Annotation
Function Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytosol {ECO:0000250}.
Disease Associations
Tissue Specificity Highly expressed in kidney, heart and brain, but low in liver. {ECO:0000269PubMed:12623130}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0005524 ATP binding
GO:0030729 acetoacetate-CoA ligase activity
GO:0047760 butyrate-CoA ligase activity
Biological Process
GO:0001889 liver development
GO:0006629 lipid metabolic process
GO:0006631 fatty acid metabolic process
GO:0007584 response to nutrient
GO:0008152 metabolic process
GO:0010243 response to organonitrogen compound
GO:0014070 response to organic cyclic compound
GO:0014074 response to purine-containing compound
GO:0032024 positive regulation of insulin secretion
GO:0034201 response to oleic acid
GO:0042493 response to drug
GO:0042594 response to starvation
GO:0045471 response to ethanol
GO:0050872 white fat cell differentiation
GO:0060612 adipose tissue development
GO:0071333 cellular response to glucose stimulus
GO:0071394 cellular response to testosterone stimulus
GO:0071397 cellular response to cholesterol
Cellular Component
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR000873 AMP-dependent synthetase/ligase
IPR005914 Acetoacetyl-CoA synthase
PFAM PF00501
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q86V21
PhosphoSite PhosphoSite-Q86V21
TrEMBL Q9H7A6
UniProt Splice Variant
Entrez Gene 65985
UniGene Hs.656073
RefSeq NP_076417
HUGO HGNC:21298
OMIM 614364
CCDS CCDS9263
HPRD 12391
IMGT
EMBL AB054121 AC122688 AK022451 AK024036 AK024760 AL833047 AY091468 BC004997 BC040490 BC040574 BC041000 BC051862 CH471054
GenPept AAH04997 AAH40490 AAH40574 AAH41000 AAH51862 AAM44124 BAB14040 BAB14793 BAB14991 BAD22560 CAH56309 EAW98474 EAW98475

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca