InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: SF3B1

Summary

InnateDB Gene

IDBG-642928.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SF3B1

Gene Name

splicing factor 3B subunit 1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000008915

Encoded Proteins

IDBP-695438

splicing factor 3b, subunit 1, 155kDa

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115524:
This gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
This gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron\'s branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:86349373-86387060

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000011734

ENSBTAP00000011734

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 105 interaction(s) predicted by orthology.

Predicted by orthology
Total	105 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0005488	binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0009952

anterior/posterior pattern specification

Cellular Component

GO:0005634	nucleus
GO:0005689	U12-type spliceosomal complex
GO:0043231	intracellular membrane-bounded organelle
GO:0071013	catalytic step 2 spliceosome

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000115524

View Gene Order

ENSMUSG00000025982

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_467

mRNA Splicing - Major Pathway pathway

REACT_1753

mRNA Splicing - Minor Pathway pathway

REACT_125

Processing of Capped Intron-Containing Pre-mRNA pathway

REACT_1735

mRNA Splicing pathway

REACT_71

Gene Expression pathway

KEGG

hsa03040

Spliceosome pathway

mmu03040

Spliceosome pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

F1MX61

UniProt Splice Variant

Entrez Gene

510177

UniGene

Bt.43697 Bt.67319 Bt.97576

RefSeq

NM_001192994 XM_005202619 XM_005202620

HUGO

HGNC:10768

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02005513 DAAA02005514

GenPept

RNA Seq Atlas

510177