Bos taurus Gene: UBE2C | |||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||
InnateDB Gene | IDBG-642958.3 | ||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||
Gene Symbol | UBE2C | ||||||||||||||||||||||||
Gene Name | Ubiquitin-conjugating enzyme E2 C | ||||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||||
Species | Bos taurus | ||||||||||||||||||||||||
Ensembl Gene | ENSBTAG00000016746 | ||||||||||||||||||||||||
Encoded Proteins |
Ubiquitin-conjugating enzyme E2 C
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Protein Structure |
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Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000175063:
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for the destruction of mitotic cyclins and for cell cycle progression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009] The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is required for the destruction of mitotic cyclins and for cell cycle progression, and may be involved in cancer progression. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been defined on chromosomes 4, 14, 15, 18, and 19. [provided by RefSeq, Aug 2013] |
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Gene Information | |||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||
Genomic Location | Chromosome 13:75306757-75310188 | ||||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||||
Band | |||||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 60 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathways | |||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||
REACTOME |
Regulation of APC/C activators between G1/S and early anaphase pathway
M Phase pathway
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins pathway
Separation of Sister Chromatids pathway
Cellular responses to stress pathway
Mitotic Metaphase and Anaphase pathway
Mitotic Anaphase pathway
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 pathway
Cell Cycle, Mitotic pathway
Phosphorylation of the APC/C pathway
Cell Cycle pathway
Cellular Senescence pathway
Mitotic Spindle Checkpoint pathway
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components pathway
APC/C:Cdc20 mediated degradation of Cyclin B pathway
Regulation of mitotic cell cycle pathway
APC/C-mediated degradation of cell cycle proteins pathway
Inactivation of APC/C via direct inhibition of the APC/C complex pathway
APC/C:Cdc20 mediated degradation of mitotic proteins pathway
Senescence-Associated Secretory Phenotype (SASP) pathway
Cell Cycle Checkpoints pathway
Autodegradation of Cdh1 by Cdh1:APC/C pathway
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase pathway
APC/C:Cdc20 mediated degradation of Securin pathway
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KEGG | |||||||||||||||||||||||||
INOH | |||||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||
REACTOME |
Inactivation of APC/C via direct inhibition of the APC/C complex pathway
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components pathway
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 pathway
APC/C:Cdc20 mediated degradation of Cyclin B pathway
APC/C:Cdc20 mediated degradation of Securin pathway
APC/C:Cdc20 mediated degradation of mitotic proteins pathway
Phosphorylation of the APC/C pathway
Autodegradation of Cdh1 by Cdh1:APC/C pathway
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase pathway
Regulation of APC/C activators between G1/S and early anaphase pathway
Separation of Sister Chromatids pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
Cellular responses to stress pathway
APC/C-mediated degradation of cell cycle proteins pathway
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins pathway
Regulation of mitotic cell cycle pathway
Cell Cycle pathway
Adaptive Immune System pathway
Mitotic Spindle Checkpoint pathway
Immune System pathway
M Phase pathway
Cellular Senescence pathway
Mitotic Anaphase pathway
Cell Cycle, Mitotic pathway
Senescence-Associated Secretory Phenotype (SASP) pathway
Class I MHC mediated antigen processing & presentation pathway
Cell Cycle Checkpoints pathway
Mitotic Metaphase and Anaphase pathway
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase pathway
Cell Cycle, Mitotic pathway
APC/C:Cdc20 mediated degradation of mitotic proteins pathway
Separation of Sister Chromatids pathway
Cellular responses to stress pathway
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins pathway
Cell Cycle pathway
APC/C-mediated degradation of cell cycle proteins pathway
M Phase pathway
Cell Cycle Checkpoints pathway
Cellular Senescence pathway
Regulation of APC/C activators between G1/S and early anaphase pathway
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 pathway
Autodegradation of Cdh1 by Cdh1:APC/C pathway
Regulation of mitotic cell cycle pathway
APC/C:Cdc20 mediated degradation of Securin pathway
Mitotic Metaphase and Anaphase pathway
Phosphorylation of the APC/C pathway
Senescence-Associated Secretory Phenotype (SASP) pathway
Inactivation of APC/C via direct inhibition of the APC/C complex pathway
Mitotic Spindle Checkpoint pathway
Mitotic Anaphase pathway
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components pathway
APC/C:Cdc20 mediated degradation of Cyclin B pathway
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KEGG |
Ubiquitin mediated proteolysis pathway
Ubiquitin mediated proteolysis pathway
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INOH | |||||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||||
SwissProt | Q32PA5 | ||||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||
Entrez Gene | 506962 | ||||||||||||||||||||||||
UniGene | |||||||||||||||||||||||||
RefSeq | NM_001037449 | ||||||||||||||||||||||||
HUGO | |||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||
CCDS | |||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||
EMBL | BC108195 | ||||||||||||||||||||||||
GenPept | AAI08196 | ||||||||||||||||||||||||
RNA Seq Atlas | 506962 | ||||||||||||||||||||||||