Version 5.4
Bos taurus Gene: IL8
Summary
InnateDB Gene IDBG-643010.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL8
Gene Name Interleukin-8
Synonyms IL-8; IL8
Species Bos taurus
Ensembl Gene ENSBTAG00000019716
Encoded Proteins
IDBP-695525
Interleukin-8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 6:90559882-90563647
Strand Forward strand
Band
Transcripts
ENSBTAT00000026275 ENSBTAP00000026275
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005153 interleukin-8 receptor binding
GO:0005515 protein binding
GO:0008009 chemokine activity
Biological Process
GO:0002237 response to molecule of bacterial origin
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007050 cell cycle arrest
GO:0030155 regulation of cell adhesion
GO:0030593 neutrophil chemotaxis
GO:0031623 receptor internalization
GO:0034976 response to endoplasmic reticulum stress
GO:0035556 intracellular signal transduction
GO:0042119 neutrophil activation
GO:0044344 cellular response to fibroblast growth factor stimulus
GO:0045091 regulation of retroviral genome replication
GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway
GO:0048566 embryonic digestive tract development
GO:0050930 induction of positive chemotaxis
GO:0071222 cellular response to lipopolysaccharide
GO:0071347 cellular response to interleukin-1
GO:0071356 cellular response to tumor necrosis factor
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_207291
PERK regulates gene expression pathway
REACT_219025
Peptide ligand-binding receptors pathway
REACT_205369
Signaling by GPCR pathway
REACT_206069
Cellular responses to stress pathway
REACT_204438
ATF4 activates genes pathway
REACT_210568
G alpha (i) signalling events pathway
REACT_214353
Signal Transduction pathway
REACT_215025
Cellular Senescence pathway
REACT_213782
Metabolism of proteins pathway
REACT_214436
GPCR downstream signaling pathway
REACT_220217
GPCR ligand binding pathway
REACT_208412
Class A/1 (Rhodopsin-like receptors) pathway
REACT_226614
Unfolded Protein Response (UPR) pathway
REACT_203215
Senescence-Associated Secretory Phenotype (SASP) pathway
REACT_212617
Chemokine receptors bind chemokines pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.49740 Bt.68106
RefSeq NM_173925
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca