InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: IL8

Summary

InnateDB Protein

IDBP-695525.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL8

Protein Name

Interleukin-8

Synonyms

IL-8; IL8;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000026275

InnateDB Gene

IDBG-643010 (IL8)

Protein Structure

UniProt Annotation

Function

IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005153	interleukin-8 receptor binding
GO:0005515	protein binding
GO:0008009	chemokine activity

Biological Process

GO:0002237	response to molecule of bacterial origin
GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007050	cell cycle arrest
GO:0030155	regulation of cell adhesion
GO:0030593	neutrophil chemotaxis
GO:0031623	receptor internalization
GO:0034976	response to endoplasmic reticulum stress
GO:0035556	intracellular signal transduction
GO:0042119	neutrophil activation
GO:0044344	cellular response to fibroblast growth factor stimulus
GO:0045091	regulation of retroviral genome replication
GO:0045744	negative regulation of G-protein coupled receptor protein signaling pathway
GO:0048566	embryonic digestive tract development
GO:0050930	induction of positive chemotaxis
GO:0071222	cellular response to lipopolysaccharide
GO:0071347	cellular response to interleukin-1
GO:0071356	cellular response to tumor necrosis factor