Version 5.4
Bos taurus Gene: UNC13D
Summary
InnateDB Gene IDBG-643146.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UNC13D
Gene Name protein unc-13 homolog D
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000013556
Encoded Proteins
IDBP-695685
unc-13 homolog D (C. elegans)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000092929:
This gene encodes a protein that is a member of the UNC13 family, containing similar domain structure as other family members but lacking an N-terminal phorbol ester-binding C1 domain present in other Munc13 proteins. The protein appears to play a role in vesicle maturation during exocytosis and is involved in regulation of cytolytic granules secretion. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis type 3, a genetically heterogeneous, rare autosomal recessive disorder. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:56402887-56418246
Strand Forward strand
Band
Transcripts
ENSBTAT00000018027 ENSBTAP00000018027
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0002432 granuloma formation
GO:0002467 germinal center formation
GO:0006909 phagocytosis
GO:0043304 regulation of mast cell degranulation
GO:0043320 natural killer cell degranulation
GO:0045921 positive regulation of exocytosis
GO:0051607 defense response to virus
Cellular Component
GO:0005764 lysosome
GO:0070382 exocytic vesicle
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000092929
View Gene Order
ENSMUSG00000057948
View Gene Order
Cross-References
SwissProt
TrEMBL E1BFF0
UniProt Splice Variant
Entrez Gene 506146
UniGene Bt.104883
RefSeq NM_001192083
HUGO HGNC:23147
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02049511
GenPept
RNA Seq Atlas 506146

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca