Version 5.4
Bos taurus Gene: CASP8
Summary
InnateDB Gene IDBG-643207.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CASP8
Gene Name caspase-8
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000015718
Encoded Proteins
IDBP-695748
caspase-8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 17213198
[Homo sapiens] CASP8 has an essential role in the regulation of NF-kappaB function in response to TLR4 stimulation, whereby CASP8 recruitment to IKBKB leads to delayed NF-kappaB nuclear translocation and impaired NF-kappaB transcriptional activity.
PMID 20019748
[Homo sapiens] CASP8 is involved in pro-apoptotic signalling through TLR3 and its activation is TICAM1 (TRIF)-dependent.
PMID 21419663
[Homo sapiens] CASP8 restricts the RIG-I-mediated activation of IRF3 by catalytically cleaving RIPK1, and subsequently converting RIPK1 from a signalling enhancer to a signalling inhibitor.
PMID 21419663
[Mus musculus] Casp8 restricts the RIG-I-mediated activation of Irf3 by catalytically cleaving Ripk1, and subsequently converting Ripk1 from a signalling enhancer to a signalling inhibitor.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000064012:
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:90278155-90301820
Strand Forward strand
Band
Transcripts
ENSBTAT00000038313 ENSBTAP00000038128
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 141 interaction(s) predicted by orthology.
Predicted by orthology
Total 141 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004175 endopeptidase activity
GO:0004197 cysteine-type endopeptidase activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008234 cysteine-type peptidase activity
GO:0016787 hydrolase activity
GO:0031625 ubiquitin protein ligase binding
GO:0035877 death effector domain binding
GO:0046982 protein heterodimerization activity
GO:0097110 scaffold protein binding
GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process
GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway
Biological Process
GO:0001525 angiogenesis
GO:0001841 neural tube formation
GO:0006508 proteolysis
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007507 heart development
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0030225 macrophage differentiation
GO:0034612 response to tumor necrosis factor
GO:0036462 TRAIL-activated apoptotic signaling pathway
GO:0042981 regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045651 positive regulation of macrophage differentiation
GO:0045862 positive regulation of proteolysis
GO:0051603 proteolysis involved in cellular protein catabolic process
GO:0060546 negative regulation of necroptotic process
GO:0070243 regulation of thymocyte apoptotic process
GO:0071260 cellular response to mechanical stimulus
GO:0097190 apoptotic signaling pathway
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097194 execution phase of apoptosis
GO:0097202 activation of cysteine-type endopeptidase activity
GO:0097284 hepatocyte apoptotic process
GO:2001233 regulation of apoptotic signaling pathway
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0030690 Noc1p-Noc2p complex
GO:0031264 death-inducing signaling complex
GO:0031265 CD95 death-inducing signaling complex
GO:0097342 ripoptosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000064012
View Gene Order
ENSMUSG00000026029
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_2
AndrogenReceptor pathway
NetPath_9
TNFalpha pathway
NetPath_26
TWEAK pathway
REACTOME
REACT_25039
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 pathway
REACT_25359
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
REACT_150361
TRIF-mediated programmed cell death pathway
REACT_6809
MyD88-independent cascade pathway
REACT_6783
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_6894
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_75776
NOD1/2 Signaling Pathway pathway
REACT_832
Dimerization of procaspase-8 pathway
REACT_1503
Caspase-8 activation by cleavage pathway
REACT_701
Activation, myristolyation of BID and translocation to mitochondria pathway
REACT_900
FasL/ CD95L signaling pathway
REACT_402
TRAIL signaling pathway
REACT_13541
Caspase-mediated cleavage of cytoskeletal proteins pathway
REACT_107
Apoptotic cleavage of cellular proteins pathway
REACT_995
Apoptotic execution phase pathway
REACT_1059
Extrinsic Pathway for Apoptosis pathway
REACT_6802
Innate Immune System pathway
REACT_6966
Toll-Like Receptors Cascades pathway
REACT_578
Apoptosis pathway
REACT_75913
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
REACT_6900
Immune System pathway
REACT_6890
Activated TLR4 signalling pathway
REACT_964
Intrinsic Pathway for Apoptosis pathway
REACT_25281
TRIF-mediated TLR3/TLR4 signaling pathway
REACT_164011
Regulation by c-FLIP pathway
REACT_1619
Death Receptor Signalling pathway
REACT_263316
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_239142
Innate Immune System pathway
REACT_258521
Apoptosis pathway
REACT_243608
Dimerization of procaspase-8 pathway
REACT_208000
Activation, myristolyation of BID and translocation to mitochondria pathway
REACT_224460
Apoptotic cleavage of cellular proteins pathway
REACT_230745
Immune System pathway
REACT_241657
Caspase-8 activation by cleavage pathway
REACT_253999
TRAIL signaling pathway
REACT_263715
FasL/ CD95L signaling pathway
REACT_210562
Caspase-mediated cleavage of cytoskeletal proteins pathway
REACT_257735
Death Receptor Signalling pathway
REACT_215122
Regulation by c-FLIP pathway
REACT_251547
Toll-Like Receptors Cascades pathway
REACT_211125
NOD1/2 Signaling Pathway pathway
REACT_196636
TRIF-mediated programmed cell death pathway
REACT_205717
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 pathway
REACT_259850
Extrinsic Pathway for Apoptosis pathway
REACT_206758
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
REACT_262462
Activated TLR4 signalling pathway
REACT_241786
MyD88-independent cascade pathway
REACT_219118
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
REACT_238546
TRIF-mediated TLR3/TLR4 signaling pathway
REACT_207035
Apoptotic execution phase pathway
REACT_246719
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_204001
Intrinsic Pathway for Apoptosis pathway
KEGG
hsa04210
Apoptosis pathway
hsa05010
Alzheimer's disease pathway
hsa04620
Toll-like receptor signaling pathway pathway
hsa04115
p53 signaling pathway pathway
hsa05016
Huntington's disease pathway
hsa05200
Pathways in cancer pathway
hsa04622
RIG-I-like receptor signaling pathway pathway
hsa04621
NOD-like receptor signaling pathway pathway
hsa05416
Viral myocarditis pathway
hsa05142
Chagas disease (American trypanosomiasis) pathway
hsa05145
Toxoplasmosis pathway
mmu04115
p53 signaling pathway pathway
mmu05010
Alzheimer's disease pathway
mmu04620
Toll-like receptor signaling pathway pathway
mmu04210
Apoptosis pathway
mmu05016
Huntington's disease pathway
mmu05200
Pathways in cancer pathway
mmu04622
RIG-I-like receptor signaling pathway pathway
mmu04621
NOD-like receptor signaling pathway pathway
mmu05416
Viral myocarditis pathway
mmu05145
Toxoplasmosis pathway
mmu05142
Chagas disease (American trypanosomiasis) pathway
INOH
INOH website
TNFR1 signaling pathway pathway
INOH website
Fas signaling pathway pathway
INOH website
TNFR1 signaling pathway pathway
INOH website
Fas signaling pathway pathway
PID NCI
ceramide_pathway
Ceramide signaling pathway
caspase_pathway
Caspase Cascade in Apoptosis
ar_pathway
Coregulation of Androgen receptor activity
avb3_integrin_pathway
Integrins in angiogenesis
tnfpathway
TNF receptor signaling pathway
trail_pathway
TRAIL signaling pathway
hivnefpathway
HIV-1 Nef: Negative effector of Fas and TNF-alpha
faspathway
FAS (CD95) signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.34170
RefSeq NM_001045970 XM_005202615
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca