InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: CASP8

Summary

InnateDB Protein

IDBP-695748.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CASP8

Protein Name

caspase-8

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000038128

InnateDB Gene

IDBG-643207 (CASP8)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 141 interaction(s) predicted by orthology.

Predicted by orthology
Total	141 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004175	endopeptidase activity
GO:0004197	cysteine-type endopeptidase activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0008234	cysteine-type peptidase activity
GO:0016787	hydrolase activity
GO:0031625	ubiquitin protein ligase binding
GO:0035877	death effector domain binding
GO:0046982	protein heterodimerization activity
GO:0097110	scaffold protein binding
GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process
GO:0097199	cysteine-type endopeptidase activity involved in apoptotic signaling pathway

Biological Process

GO:0001525	angiogenesis
GO:0001841	neural tube formation
GO:0006508	proteolysis
GO:0006915	apoptotic process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007507	heart development
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors
GO:0030225	macrophage differentiation
GO:0034612	response to tumor necrosis factor
GO:0036462	TRAIL-activated apoptotic signaling pathway
GO:0042981	regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045651	positive regulation of macrophage differentiation
GO:0045862	positive regulation of proteolysis
GO:0051603	proteolysis involved in cellular protein catabolic process
GO:0060546	negative regulation of necroptotic process
GO:0070243	regulation of thymocyte apoptotic process
GO:0071260	cellular response to mechanical stimulus
GO:0097190	apoptotic signaling pathway
GO:0097191	extrinsic apoptotic signaling pathway
GO:0097194	execution phase of apoptosis
GO:0097202	activation of cysteine-type endopeptidase activity
GO:0097284	hepatocyte apoptotic process
GO:2001233	regulation of apoptotic signaling pathway
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005815	microtubule organizing center
GO:0005829	cytosol
GO:0030690	Noc1p-Noc2p complex
GO:0031264	death-inducing signaling complex
GO:0031265	CD95 death-inducing signaling complex
GO:0097342	ripoptosome

Protein Structure and Domains

PDB ID

InterPro

IPR001309 Peptidase C14, ICE, catalytic subunit p20
IPR001875 Death effector domain
IPR002138 Peptidase C14, caspase non-catalytic subunit p10
IPR011029 Death-like domain
IPR011600 Peptidase C14, caspase domain
IPR015917 Peptidase C14A, caspase precursor p45, core

PFAM

PF01335
PF00656

PRINTS

PR00376

PIRSF

SMART

SM00031
SM00115

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

Q2LGB8

UniProt Splice Variant

Entrez Gene

507481

UniGene

Bt.34170

RefSeq

NP_001039435

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC134534 BT030512 DAAA02005591 DQ319070

GenPept

AAI34535 ABC47873 ABQ12952