Version 5.4
Bos taurus Gene: BT.61987
Summary
InnateDB Gene IDBG-643208.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.61987
Gene Name zinc finger protein SNAI1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000014554
Encoded Proteins
IDBP-695749
zinc finger protein SNAI1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000124216:
The Drosophila embryonic protein snail is a zinc finger transcriptional repressor which downregulates the expression of ectodermal genes within the mesoderm. The nuclear protein encoded by this gene is structurally similar to the Drosophila snail protein, and is also thought to be critical for mesoderm formation in the developing embryo. At least two variants of a similar processed pseudogene have been found on chromosome 2. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:78766068-78772194
Strand Forward strand
Band
Transcripts
ENSBTAT00000019345 ENSBTAP00000019345
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.
Predicted by orthology
Total 29 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001227 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003676 nucleic acid binding
GO:0005515 protein binding
GO:0019900 kinase binding
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001649 osteoblast differentiation
GO:0001707 mesoderm formation
GO:0001837 epithelial to mesenchymal transition
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007498 mesoderm development
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0010957 negative regulation of vitamin D biosynthetic process
GO:0016477 cell migration
GO:0030335 positive regulation of cell migration
GO:0031069 hair follicle morphogenesis
GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0060021 palate development
GO:0060536 cartilage morphogenesis
GO:0060707 trophoblast giant cell differentiation
GO:0060806 negative regulation of cell differentiation involved in embryonic placenta development
GO:0060972 left/right pattern formation
GO:0061314 Notch signaling involved in heart development
GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:2000810 regulation of tight junction assembly
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000124216
View Gene Order
ENSMUSG00000042821
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04520
Adherens junction pathway
mmu04520
Adherens junction pathway
INOH
PID NCI
met_pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
myc_activpathway
Validated targets of C-MYC transcriptional activation
ilk_pathway
Integrin-linked kinase signaling
Cross-References
SwissProt
TrEMBL E1BMI0
UniProt Splice Variant
Entrez Gene 504492
UniGene Bt.61987
RefSeq NM_001112708
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02036843
GenPept
RNA Seq Atlas 504492

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca