Version 5.4
Bos taurus Gene: BT.87535
Summary
InnateDB Gene IDBG-643225.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.87535
Gene Name 4-hydroxybenzoate polyprenyltransferase, mitochondrial precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000005744
Encoded Proteins
IDBP-695767
para-hydroxybenzoate--polyprenyltransferase, mitochondrial precursor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000173085:
This gene encodes an enzyme that functions in the final steps in the biosynthesis of CoQ (ubiquinone), a redox carrier in the mitochondrial respiratory chain and a lipid-soluble antioxidant. This enzyme, which is part of the coenzyme Q10 pathway, catalyzes the prenylation of parahydroxybenzoate with an all-trans polyprenyl group. Mutations in this gene cause coenzyme Q10 deficiency, a mitochondrial encephalomyopathy, and also COQ2 nephropathy, an inherited form of mitochondriopathy with primary renal involvement. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:99812238-99839387
Strand Reverse strand
Band
Transcripts
ENSBTAT00000007549 ENSBTAP00000007549
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004659 prenyltransferase activity
GO:0016740 transferase activity
Biological Process
GO:0006071 glycerol metabolic process
GO:0006744 ubiquinone biosynthetic process
GO:0009058 biosynthetic process
Cellular Component
GO:0005739 mitochondrion
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000173085
View Gene Order
ENSMUSG00000029319
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_118595
Mitochondrial protein import pathway
REACT_160111
Ubiquinol biosynthesis pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_17015
Metabolism of proteins pathway
REACT_111217
Metabolism pathway
REACT_188937
Metabolism pathway
REACT_247926
Metabolism of proteins pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_199101
Mitochondrial protein import pathway
REACT_196568
Ubiquinol biosynthesis pathway
KEGG
hsa00130
Ubiquinone and other terpenoid-quinone biosynthesis pathway
mmu00130
Ubiquinone and other terpenoid-quinone biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F1N1G6
UniProt Splice Variant
Entrez Gene 504633
UniGene Bt.87535
RefSeq NM_001045893
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02018273
GenPept
RNA Seq Atlas 504633

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca