InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Coq2

Summary

InnateDB Gene

IDBG-183364.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Coq2

Gene Name

coenzyme Q2 homolog, prenyltransferase (yeast)

Synonyms

2310002F18Rik

Species

Mus musculus

Ensembl Gene

ENSMUSG00000029319

Encoded Proteins

IDBP-183366

coenzyme Q2 homolog, prenyltransferase (yeast)

IDBP-540477

coenzyme Q2 homolog, prenyltransferase (yeast)

IDBP-536662

coenzyme Q2 homolog, prenyltransferase (yeast)

IDBP-542764

coenzyme Q2 homolog, prenyltransferase (yeast)

IDBP-536186

coenzyme Q2 homolog, prenyltransferase (yeast)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000173085:
This gene encodes an enzyme that functions in the final steps in the biosynthesis of CoQ (ubiquinone), a redox carrier in the mitochondrial respiratory chain and a lipid-soluble antioxidant. This enzyme, which is part of the coenzyme Q10 pathway, catalyzes the prenylation of parahydroxybenzoate with an all-trans polyprenyl group. Mutations in this gene cause coenzyme Q10 deficiency, a mitochondrial encephalomyopathy, and also COQ2 nephropathy, an inherited form of mitochondriopathy with primary renal involvement. [provided by RefSeq, Oct 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:100654723-100675140

Strand

Reverse strand

Band

Transcripts

ENSMUST00000031262	ENSMUSP00000031262
ENSMUST00000135146	ENSMUSP00000122631
ENSMUST00000126981	ENSMUSP00000122296
ENSMUST00000135801	ENSMUSP00000119410
ENSMUST00000127811	ENSMUSP00000115605

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002083	4-hydroxybenzoate decaprenyltransferase activity
GO:0004659	prenyltransferase activity
GO:0016740	transferase activity
GO:0047293	4-hydroxybenzoate nonaprenyltransferase activity

Biological Process

GO:0006071	glycerol metabolic process
GO:0006744	ubiquinone biosynthetic process
GO:0008152	metabolic process
GO:0008299	isoprenoid biosynthetic process
GO:0009058	biosynthetic process