InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: DNMT1

Summary

InnateDB Gene

IDBG-643228.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DNMT1

Gene Name

DNA (cytosine-5)-methyltransferase 1

Synonyms

DNMT

Species

Bos taurus

Ensembl Gene

ENSBTAG00000002736

Encoded Proteins

IDBP-695784

DNA (cytosine-5)-methyltransferase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000130816:
DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:15913446-15956917

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000003549

ENSBTAP00000003549

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 101 interaction(s) predicted by orthology.

Predicted by orthology
Total	101 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003723	RNA binding
GO:0003886	DNA (cytosine-5-)-methyltransferase activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0008168	methyltransferase activity
GO:0008270	zinc ion binding
GO:0008327	methyl-CpG binding
GO:0009008	DNA-methyltransferase activity
GO:0016740	transferase activity
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006306	DNA methylation
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0010216	maintenance of DNA methylation
GO:0010468	regulation of gene expression
GO:0010628	positive regulation of gene expression
GO:0016458	gene silencing
GO:0016568	chromatin modification
GO:0032259	methylation
GO:0042127	regulation of cell proliferation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0051571	positive regulation of histone H3-K4 methylation
GO:0051573	negative regulation of histone H3-K9 methylation
GO:0071230	cellular response to amino acid stimulus
GO:0090116	C-5 methylation of cytosine