InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Dnmt1

Summary

InnateDB Gene

IDBG-138141.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dnmt1

Gene Name

DNA methyltransferase (cytosine-5) 1

Synonyms

Cxxc9; Dnmt; Dnmt1o; m.MmuI; MCMT; Met-1; Met1; MommeD2; MTase

Species

Mus musculus

Ensembl Gene

ENSMUSG00000004099

Encoded Proteins

IDBP-138143

DNA methyltransferase (cytosine-5) 1

IDBP-741871

IDBP-742502

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000130816:
DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:20907206-20959888

Strand

Reverse strand

Band

Transcripts

ENSMUST00000004202	ENSMUSP00000004202
ENSMUST00000177754	ENSMUSP00000136982
ENSMUST00000178110	ENSMUSP00000136669

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
They are also associated with 96 interaction(s) predicted by orthology.

Experimentally validated
Total	40 [view]
Protein-Protein	36 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	96 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003723	RNA binding
GO:0003886	DNA (cytosine-5-)-methyltransferase activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0008168	methyltransferase activity
GO:0008270	zinc ion binding
GO:0008327	methyl-CpG binding
GO:0009008	DNA-methyltransferase activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006306	DNA methylation
GO:0006351	transcription, DNA-templated
GO:0010216	maintenance of DNA methylation
GO:0010468	regulation of gene expression
GO:0010628	positive regulation of gene expression
GO:0016458	gene silencing
GO:0016568	chromatin modification
GO:0042127	regulation of cell proliferation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0051571	positive regulation of histone H3-K4 methylation
GO:0051573	negative regulation of histone H3-K9 methylation
GO:0071230	cellular response to amino acid stimulus
GO:0090116	C-5 methylation of cytosine