Version 5.4
Homo sapiens Gene: SPAG8
Summary
InnateDB Gene IDBG-64330.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPAG8
Gene Name sperm associated antigen 8
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000137098
Encoded Proteins
IDBP-64334
sperm associated antigen 8
IDBP-237078
sperm associated antigen 8
IDBP-483510
sperm associated antigen 8
IDBP-475625
sperm associated antigen 8
IDBP-478657
sperm associated antigen 8
IDBP-474705
sperm associated antigen 8
IDBP-480924
sperm associated antigen 8
IDBP-479325
sperm associated antigen 8
IDBP-808853
sperm associated antigen 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein encoded by this gene is recognized by sperm agglutinating antibodies from an infertile woman. This protein is localized in germ cells of the testis at all stages of spermatogenesis and is localized to the acrosomal region of mature spermatozoa. This protein interacts with ACT (activator of CREM in testis) and may play a role in CREM (cAMP response element modulator)-ACT-mediated gene transcription during spermatogenesis. This protein may also play a role in spermatogenesis by regulating microtubule formation and cell division. Alternatively spliced variants that encode different protein isoforms have been described but the full-length sequences of only two have been determined. [provided by RefSeq, Jul 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:35808045-35812272
Strand Reverse strand
Band p13.3
Transcripts
ENST00000340291 ENSP00000340982
ENST00000396638 ENSP00000379878
ENST00000460836
ENST00000463889
ENST00000475644 ENSP00000418530
ENST00000489063
ENST00000484764 ENSP00000418072
ENST00000497810 ENSP00000417462
ENST00000479751
ENST00000495667 ENSP00000420413
ENST00000472605 ENSP00000418215
ENST00000471631 ENSP00000419280
ENST00000620013 ENSP00000478973
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
Experimentally validated
Total 19 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
GO:0008017 microtubule binding
Biological Process
GO:0008150 biological_process
GO:0032092 positive regulation of protein binding
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0001669 acrosomal vesicle
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000066196
View Gene Order
ENSBTAG00000011442
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001039592 NM_172312 XM_005251436 XM_006716753
HUGO
OMIM
CCDS CCDS43798 CCDS6592
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca