Version 5.4
Homo sapiens Protein: SPAG8
Summary
InnateDB Protein IDBP-483510.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPAG8
Protein Name sperm associated antigen 8
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000418530
InnateDB Gene IDBG-64330 (SPAG8)
Protein Structure
UniProt Annotation
Function May play a role in fertility and microtubule formation through interaction with RANBP9. {ECO:0000269PubMed:10500252}.
Subcellular Localization Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269PubMed:15014887, ECO:0000269PubMed:8788182}. Note=Acrosomal region of the head of mature sperm cells.
Disease Associations
Tissue Specificity Expressed in testis (germ cells), but not in liver, kidney, prostate and small intestine. {ECO:0000269PubMed:8788182}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
Experimentally validated
Total 19 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0008017 microtubule binding
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0001669 acrosomal vesicle
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR000104 Antifreeze protein, type I
PFAM
PRINTS PR00308
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q99932
PhosphoSite PhosphoSite-Q99932
TrEMBL F8WBP3
UniProt Splice Variant
Entrez Gene 26206
UniGene Hs.256747
RefSeq XP_005251495
HUGO HGNC:14105
OMIM 605731
CCDS
HPRD 12039
IMGT
EMBL AK302313 AL133410 BC019247 S83157 U12978
GenPept AAA21129 AAB46833 AAH19247 BAG63651 CAI10989

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca