InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: DAK

Summary

InnateDB Gene

IDBG-643400.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DAK

Gene Name

bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing)

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000018201

Encoded Proteins

IDBP-695965

bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000149476:
This gene is a member of the family of dihydroxyacetone kinases, which have a protein structure distinct from other kinases. The product of this gene phosphorylates dihydroxyacetone, and also catalyzes the formation of riboflavin 4',5'-phosphate (aka cyclin FMN) from FAD. Several alternatively spliced transcript variants have been identified, but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]
This gene is a member of the family of dihydroxyacetone kinases, which have a protein structure distinct from other kinases. The product of this gene phosphorylates dihydroxyacetone, and also catalyzes the formation of riboflavin 4\',5\'-phosphate (aka cyclin FMN) from FAD. Several alternatively spliced transcript variants have been identified, but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 29:40537653-40549701

Strand

Forward strand

Band

Transcripts

ENSBTAT00000024227

ENSBTAP00000024227

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004371	glycerone kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0034012	FAD-AMP lyase (cyclizing) activity
GO:0050354	triokinase activity

Biological Process

GO:0006071	glycerol metabolic process
GO:0016310	phosphorylation
GO:0044262	cellular carbohydrate metabolic process
GO:0045088	regulation of innate immune response
GO:0046835	carbohydrate phosphorylation

Cellular Component

GO:0005634	nucleus
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000149476

View Gene Order

ENSMUSG00000034371

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_25359

RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway

REACT_6802

Innate Immune System pathway

REACT_6900

Immune System pathway

KEGG

hsa00561

Glycerolipid metabolism pathway

hsa04622

RIG-I-like receptor signaling pathway pathway

mmu00561

Glycerolipid metabolism pathway

mmu04622

RIG-I-like receptor signaling pathway pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

A0JN77

UniProt Splice Variant

Entrez Gene

512373

UniGene

Bt.3266

RefSeq

NM_001024524 XM_005226906

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC126551 DAAA02063463

GenPept

AAI26552

RNA Seq Atlas

512373