InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: DAK

Summary

InnateDB Gene

IDBG-50063.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DAK

Gene Name

dihydroxyacetone kinase 2 homolog (S. cerevisiae)

Synonyms

NET45

Species

Homo sapiens

Ensembl Gene

ENSG00000149476

Encoded Proteins

IDBP-240650

dihydroxyacetone kinase 2 homolog (S. cerevisiae)

IDBP-719053

IDBP-585244

dihydroxyacetone kinase 2 homolog (S. cerevisiae)

IDBP-583642

dihydroxyacetone kinase 2 homolog (S. cerevisiae)

IDBP-589438

dihydroxyacetone kinase 2 homolog (S. cerevisiae)

IDBP-807440

dihydroxyacetone kinase 2 homolog (S. cerevisiae)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is a member of the family of dihydroxyacetone kinases, which have a protein structure distinct from other kinases. The product of this gene phosphorylates dihydroxyacetone, and also catalyzes the formation of riboflavin 4',5'-phosphate (aka cyclin FMN) from FAD. Several alternatively spliced transcript variants have been identified, but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]
This gene is a member of the family of dihydroxyacetone kinases, which have a protein structure distinct from other kinases. The product of this gene phosphorylates dihydroxyacetone, and also catalyzes the formation of riboflavin 4\',5\'-phosphate (aka cyclin FMN) from FAD. Several alternatively spliced transcript variants have been identified, but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:61333210-61353295

Strand

Forward strand

Band

q12.2

Transcripts

ENST00000394900	ENSP00000378360
ENST00000534084	ENSP00000459382
ENST00000531820
ENST00000530456
ENST00000532173	ENSP00000431844
ENST00000530057
ENST00000525170
ENST00000529121
ENST00000529620
ENST00000533393
ENST00000524968	ENSP00000434405
ENST00000529479	ENSP00000432539
ENST00000529092
ENST00000533853
ENST00000524953
ENST00000534134
ENST00000534370
ENST00000528061
ENST00000525366
ENST00000524440
ENST00000530329
ENST00000617083	ENSP00000478735

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.

Experimentally validated
Total	21 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004371	glycerone kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0034012	FAD-AMP lyase (cyclizing) activity
GO:0046872	metal ion binding
GO:0050354	triokinase activity

Biological Process

GO:0006071	glycerol metabolic process
GO:0016310	phosphorylation
GO:0044262	cellular carbohydrate metabolic process
GO:0045087	innate immune response
GO:0045088	regulation of innate immune response
GO:0046835	carbohydrate phosphorylation

Cellular Component

GO:0005634	nucleus
GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000034371

View Gene Order

ENSBTAG00000018201

Not yet available

Pathways

NETPATH

REACTOME

REACT_25359

RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway

REACT_6802

Innate Immune System pathway

REACT_6900

Immune System pathway

KEGG

hsa00561

Glycerolipid metabolism pathway

hsa04622

RIG-I-like receptor signaling pathway pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

I3L252

UniProt Splice Variant

Entrez Gene

26007

UniGene

Hs.6278 Hs.739680

RefSeq

NM_015533 XM_006718496 XM_006718497

HUGO

HGNC:24552

OMIM

615844

CCDS

CCDS8003

HPRD

13180

IMGT

EMBL

AP003108

GenPept

RNA Seq Atlas

26007