Version 5.4
Bos taurus Gene: RTTN
Summary
InnateDB Gene IDBG-643514.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RTTN
Gene Name rotatin
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000013221
Encoded Proteins
IDBP-696104
rotatin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000176225:
This gene encodes a large protein whose specific function is unknown. Absence of the orthologous protein in mouse results in embryonic lethality with deficient axial rotation, abnormal differentiation of the neural tube, and randomized looping of the heart tube during development. In human, mutations in this gene are associated with polymicrogyria with seizures. In human fibroblasts this protein localizes at the ciliary basal bodies. Given the intracellular localization of this protein and the phenotypic effects of mutations, this gene is suspected of playing a role in the maintenance of normal ciliary structure which in turn effects the developmental process of left-right organ specification, axial rotation, and perhaps notochord development. [provided by RefSeq, Jan 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 24:7401048-7519745
Strand Forward strand
Band
Transcripts
ENSBTAT00000017595 ENSBTAP00000017595
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
Biological Process
GO:0007368 determination of left/right symmetry
Cellular Component
GO:0036064 ciliary basal body
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000176225
View Gene Order
ENSMUSG00000023066
View Gene Order
Cross-References
SwissProt
TrEMBL E1BG09
UniProt Splice Variant
Entrez Gene 615378
UniGene Bt.22300
RefSeq NM_001206207 XM_005224039
HUGO HGNC:18654
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02056161 DAAA02056162
GenPept
RNA Seq Atlas 615378

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca