Version 5.4
Bos taurus Gene: VPS28
Summary
InnateDB Gene IDBG-643527.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VPS28
Gene Name Vacuolar protein sorting-associated protein 28 homolog
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000026320
Encoded Proteins
IDBP-696085
vacuolar protein sorting 28 homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000160948:
This gene encodes a protein involved in endosomal sorting of cell surface receptors via a multivesicular body/late endosome pathway. The encoded protein is one of the three subunits of the ESCRT-I complex (endosomal complexes required for transport) involved in the sorting of ubiquitinated proteins. The two other subunits of ESCRT-I are vesicular protein sorting 23, also known as tumor susceptibility gene 101 (TSG101), and vesicular protein sorting 37. Two alternative transcripts encoding different isoforms have been described. Additional alternative transcripts may exist but the proteins encoded by these transcripts have not been verified experimentally. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:1693641-1698490
Strand Forward strand
Band
Transcripts
ENSBTAT00000054515 ENSBTAP00000049263
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0031397 negative regulation of protein ubiquitination
Cellular Component
GO:0000813 ESCRT I complex
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000160948
View Gene Order
null
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_115893
Membrane binding and targetting of GAG proteins pathway
REACT_6361
Late Phase of HIV Life Cycle pathway
REACT_27258
Endosomal Sorting Complex Required For Transport (ESCRT) pathway
REACT_115860
Synthesis And Processing Of GAG, GAGPOL Polyproteins pathway
REACT_6256
HIV Life Cycle pathway
REACT_6185
HIV Infection pathway
REACT_6818
Assembly Of The HIV Virion pathway
REACT_6359
Budding and maturation of HIV virion pathway
REACT_116125
Disease pathway
REACT_11123
Membrane Trafficking pathway
KEGG
hsa04144
Endocytosis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca