InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: EPOR

Summary

InnateDB Gene

IDBG-643528.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EPOR

Gene Name

erythropoietin receptor precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000008197

Encoded Proteins

IDBP-696090

erythropoietin receptor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 8068943

[Homo sapiens] EPOR, a member of the cytokine receptor superfamily, associates with the JAK2 protein tyrosine kinase upon erythropoietin stimulation, inducing tyrosine phosphorylation of cellular substrates, including the EPOR, to transduce a growth signal.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000187266:
This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:16998453-17003707

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000010781

ENSBTAP00000010781

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 42 interaction(s) predicted by orthology.

Predicted by orthology
Total	42 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004896	cytokine receptor activity
GO:0004900	erythropoietin receptor activity
GO:0005515	protein binding
GO:0042802	identical protein binding

Biological Process

GO:0007165	signal transduction
GO:0007420	brain development
GO:0007507	heart development
GO:0038162	erythropoietin-mediated signaling pathway
GO:0046697	decidualization