Version 5.4
Mus musculus Gene: Epor
Summary
InnateDB Gene IDBG-142378.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Epor
Gene Name erythropoietin receptor
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000006235
Encoded Proteins
IDBP-142380
erythropoietin receptor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 8068943
[Homo sapiens] EPOR, a member of the cytokine receptor superfamily, associates with the JAK2 protein tyrosine kinase upon erythropoietin stimulation, inducing tyrosine phosphorylation of cellular substrates, including the EPOR, to transduce a growth signal.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000187266:
This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:21958899-21963576
Strand Reverse strand
Band A3
Transcripts
ENSMUST00000006397 ENSMUSP00000006397
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.
Experimentally validated
Total 27 [view]
Protein-Protein 27 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 36 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0004900 erythropoietin receptor activity
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0003007 heart morphogenesis
GO:0007165 signal transduction
GO:0007420 brain development
GO:0007507 heart development
GO:0016032 viral process
GO:0038162 erythropoietin-mediated signaling pathway
GO:0046697 decidualization
GO:0055008 cardiac muscle tissue morphogenesis
GO:0055010 ventricular cardiac muscle tissue morphogenesis
GO:0060979 vasculogenesis involved in coronary vascular morphogenesis
GO:0061032 visceral serous pericardium development
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000187266
View Gene Order
ENSBTAG00000008197
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04060
Cytokine-cytokine receptor interaction pathway
mmu04630
Jak-STAT signaling pathway pathway
mmu04640
Hematopoietic cell lineage pathway
INOH
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_6
KitReceptor pathway
REACTOME
KEGG
hsa04640
Hematopoietic cell lineage pathway
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04630
Jak-STAT signaling pathway pathway
INOH
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
PID NCI
epopathway
EPO signaling pathway
kitpathway
Signaling events mediated by Stem cell factor receptor (c-Kit)
Cross-References
SwissProt P14753
TrEMBL Q3UTV9
UniProt Splice Variant
Entrez Gene 13857
UniGene Mm.2653
RefSeq NM_010149 XM_006509998
OMIM
CCDS CCDS22915
HPRD
IMGT
MGI ID MGI:95408
MGI Symbol Epor
EMBL AK139031 BC003953 BC046282 CH466522 J04843 M38133 M62360 S59388 X53081
GenPept AAA37571 AAA37572 AAA37582 AAB20029 AAH03953 AAH46282 BAE23871 CAA37248 EDL25236
RNA Seq Atlas 13857

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca