Version 5.4
Bos taurus Gene: SLC39A4
Summary
InnateDB Gene IDBG-643529.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC39A4
Gene Name Zinc transporter ZIP4
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000046026
Encoded Proteins
IDBP-696088
Zinc transporter ZIP4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000147804:
This gene encodes a member of the zinc/iron-regulated transporter-like protein (ZIP) family. The transmembrane protein is required for zinc uptake in the intestine. Mutations in this gene result in acrodermatitis enteropathica, a rare inherited defect in the absorption of dietary zinc. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:1719732-1724220
Strand Forward strand
Band
Transcripts
ENSBTAT00000012255 ENSBTAP00000012255
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005385 zinc ion transmembrane transporter activity
GO:0046873 metal ion transmembrane transporter activity
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0006829 zinc ion transport
GO:0006882 cellular zinc ion homeostasis
GO:0030001 metal ion transport
GO:0034224 cellular response to zinc ion starvation
GO:0055085 transmembrane transport
GO:0071577 zinc ion transmembrane transport
Cellular Component
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0016324 apical plasma membrane
GO:0055038 recycling endosome membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000147804
View Gene Order
ENSMUSG00000063354
View Gene Order
Pathways
NETPATH
REACTOME
REACT_222460
SLC-mediated transmembrane transport pathway
REACT_208122
Zinc transporters pathway
REACT_221584
Metal ion SLC transporters pathway
REACT_223103
Transmembrane transport of small molecules pathway
REACT_219894
Zinc influx into cells by the SLC39 gene family pathway
REACT_212003
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_20603
Zinc influx into cells by the SLC39 gene family pathway
REACT_20547
Metal ion SLC transporters pathway
REACT_19305
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_20530
Zinc transporters pathway
REACT_19118
SLC-mediated transmembrane transport pathway
REACT_217615
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway
REACT_247550
SLC-mediated transmembrane transport pathway
REACT_198240
Zinc influx into cells by the SLC39 gene family pathway
REACT_243781
Zinc transporters pathway
REACT_253400
Transmembrane transport of small molecules pathway
REACT_251299
Metal ion SLC transporters pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q1KZG0
TrEMBL
UniProt Splice Variant
Entrez Gene 510951
UniGene Bt.105835 Bt.55753
RefSeq NM_001046067
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC116012 DQ336345 DQ336346
GenPept AAI16013 ABC69723 ABC69724
RNA Seq Atlas 510951
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca