Version 5.4
Bos taurus Protein: SLC39A4
Summary
InnateDB Protein IDBP-696088.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC39A4
Protein Name Zinc transporter ZIP4
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000012255
InnateDB Gene IDBG-643529 (SLC39A4)
Protein Structure
UniProt Annotation
Function Plays an important role in cellular zinc homeostasis as a zinc transporter. Regulated in response to zinc availability (By similarity). {ECO:0000250UniProtKB:Q78IQ7}.
Subcellular Localization Cell membrane {ECO:0000250UniProtKB:Q78IQ7}; Multi-pass membrane protein {ECO:0000250UniProtKB:Q78IQ7}. Recycling endosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250UniProtKB:Q78IQ7}. Note=Colocalized with TFRC in the recycling endosomes. Cycles between endosomal compartments and the plasma membrane in response to zinc availability (By similarity). {ECO:0000250UniProtKB:Q78IQ7}.
Disease Associations Note=Defects in SLC39A4 are the cause of bovine hereditary zinc-deficiency (BHZD); also known as lethal trait A46, Adema disease, hereditary parakeratosis, and hereditary thymus hypoplasia. BHZD is a autosomal recessive disease caused by the inability to absorb sufficient zinc. The symptoms are diarrhea, immune system dysfunction, skin lesions and death if untreated. Oral zinc supplementation allows symptom free development of calves.
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005385 zinc ion transmembrane transporter activity
GO:0046873 metal ion transmembrane transporter activity
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0006829 zinc ion transport
GO:0006882 cellular zinc ion homeostasis
GO:0030001 metal ion transport
GO:0034224 cellular response to zinc ion starvation
GO:0055085 transmembrane transport
GO:0071577 zinc ion transmembrane transport
Cellular Component
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0016324 apical plasma membrane
GO:0055038 recycling endosome membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR003689 Zinc/iron permease
PFAM PF02535
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q1KZG0
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 510951
UniGene Bt.55753
RefSeq NP_001039532
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC116012 DQ336345 DQ336346
GenPept AAI16013 ABC69723 ABC69724

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca