Version 5.4
Bos taurus Gene: MAP2K6
Summary
InnateDB Gene IDBG-643571.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAP2K6
Gene Name Dual specificity mitogen-activated protein kinase kinase 6
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000001609
Encoded Proteins
IDBP-696133
Dual specificity mitogen-activated protein kinase kinase 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 9841871
[Homo sapiens] MAP2K6 activates MAPK14 (p38) MAP kinases.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000108984:
This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:61708769-61814973
Strand Reverse strand
Band
Transcripts
ENSBTAT00000002115 ENSBTAP00000002115
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019901 protein kinase binding
Biological Process
GO:0000165 MAPK cascade
GO:0000187 activation of MAPK activity
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0006950 response to stress
GO:0016310 phosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0060048 cardiac muscle contraction
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000108984
View Gene Order
ENSMUSG00000020623
View Gene Order
Pathways
NETPATH
REACTOME
REACT_224941
NOD1/2 Signaling Pathway pathway
REACT_218237
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_210286
TRIF-mediated TLR3/TLR4 signaling pathway
REACT_216172
Myogenesis pathway
REACT_224703
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_205566
Activated TLR4 signalling pathway
REACT_222278
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
REACT_224546
MyD88-independent cascade pathway
REACT_207897
activated TAK1 mediates p38 MAPK activation pathway
REACT_217035
Toll Like Receptor 9 (TLR9) Cascade pathway
REACT_227345
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_210224
Toll Like Receptor 5 (TLR5) Cascade pathway
REACT_213612
Cytokine Signaling in Immune system pathway
REACT_206069
Cellular responses to stress pathway
REACT_213138
Immune System pathway
REACT_227036
MAP kinase activation in TLR cascade pathway
REACT_219220
Toll-Like Receptors Cascades pathway
REACT_215025
Cellular Senescence pathway
REACT_219947
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
REACT_223848
Toll Like Receptor 10 (TLR10) Cascade pathway
REACT_225657
Oxidative Stress Induced Senescence pathway
REACT_225653
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_218091
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
REACT_216676
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_219586
MyD88 dependent cascade initiated on endosome pathway
REACT_207559
CDO in myogenesis pathway
REACT_216714
Innate Immune System pathway
REACT_207826
Interleukin-1 signaling pathway
REACT_206833
Signaling by Interleukins pathway
REACT_211704
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_217527
MyD88 cascade initiated on plasma membrane pathway
REACT_220844
Developmental Biology pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_7
TGF_beta_Receptor pathway
NetPath_9
TNFalpha pathway
NetPath_13
IL1 pathway
NetPath_18
IL6 pathway
NetPath_21
RANKL pathway
NetPath_22
Leptin pathway
NetPath_23
TSH pathway
REACTOME
REACT_21399
activated TAK1 mediates p38 MAPK activation pathway
REACT_6809
MyD88-independent cascade pathway
REACT_6783
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_6788
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_8005
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_8006
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_25024
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
REACT_25222
MyD88 dependent cascade initiated on endosome pathway
REACT_9047
Toll Like Receptor 9 (TLR9) Cascade pathway
REACT_27215
MyD88 cascade initiated on plasma membrane pathway
REACT_9027
Toll Like Receptor 10 (TLR10) Cascade pathway
REACT_6894
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_9061
Toll Like Receptor 5 (TLR5) Cascade pathway
REACT_75776
NOD1/2 Signaling Pathway pathway
REACT_22442
Interleukin-1 signaling pathway
REACT_21402
CDO in myogenesis pathway
REACT_120956
Cellular responses to stress pathway
REACT_111045
Developmental Biology pathway
REACT_9020
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_6802
Innate Immune System pathway
REACT_7980
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_6966
Toll-Like Receptors Cascades pathway
REACT_21308
MAP kinase activation in TLR cascade pathway
REACT_21303
Myogenesis pathway
REACT_75913
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
REACT_6900
Immune System pathway
REACT_169274
Cellular Senescence pathway
REACT_22232
Signaling by Interleukins pathway
REACT_6890
Activated TLR4 signalling pathway
REACT_25281
TRIF-mediated TLR3/TLR4 signaling pathway
REACT_169436
Oxidative Stress Induced Senescence pathway
REACT_263316
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_229712
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
REACT_263004
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_239142
Innate Immune System pathway
REACT_188970
Oxidative Stress Induced Senescence pathway
REACT_188957
Cellular responses to stress pathway
REACT_245896
MyD88 cascade initiated on plasma membrane pathway
REACT_233584
Cytokine Signaling in Immune system pathway
REACT_255939
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_262171
MAP kinase activation in TLR cascade pathway
REACT_230745
Immune System pathway
REACT_253473
Myogenesis pathway
REACT_260773
Toll Like Receptor 5 (TLR5) Cascade pathway
REACT_254406
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_237946
activated TAK1 mediates p38 MAPK activation pathway
REACT_188820
Cellular Senescence pathway
REACT_249409
Toll Like Receptor 9 (TLR9) Cascade pathway
REACT_258600
CDO in myogenesis pathway
REACT_251547
Toll-Like Receptors Cascades pathway
REACT_261687
Signaling by Interleukins pathway
REACT_211125
NOD1/2 Signaling Pathway pathway
REACT_256727
MyD88 dependent cascade initiated on endosome pathway
REACT_188576
Developmental Biology pathway
REACT_206758
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
REACT_262462
Activated TLR4 signalling pathway
REACT_224208
Interleukin-1 signaling pathway
REACT_241786
MyD88-independent cascade pathway
REACT_242921
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
REACT_230045
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_238546
TRIF-mediated TLR3/TLR4 signaling pathway
REACT_261340
Toll Like Receptor 10 (TLR10) Cascade pathway
REACT_246719
Toll Like Receptor 4 (TLR4) Cascade pathway
KEGG
hsa04912
GnRH signaling pathway pathway
hsa04664
Fc epsilon RI signaling pathway pathway
hsa04010
MAPK signaling pathway pathway
hsa04620
Toll-like receptor signaling pathway pathway
hsa05014
Amyotrophic lateral sclerosis (ALS) pathway
hsa04380
Osteoclast differentiation pathway
hsa05145
Toxoplasmosis pathway
mmu04620
Toll-like receptor signaling pathway pathway
mmu04664
Fc epsilon RI signaling pathway pathway
mmu04912
GnRH signaling pathway pathway
mmu04010
MAPK signaling pathway pathway
mmu05014
Amyotrophic lateral sclerosis (ALS) pathway
mmu04380
Osteoclast differentiation pathway
mmu05145
Toxoplasmosis pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
IL-1 signaling pathway pathway
INOH website
Toll-like receptor signaling pathway pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
INOH website
TGF-beta signaling pathway
INOH website
BMP2 signaling pathway
INOH website
IL-7 signaling pathway
INOH website
IL-1 signaling pathway pathway
INOH website
Toll-like receptor signaling pathway pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
INOH website
BMP2 signaling pathway
INOH website
TGF-beta signaling pathway
PID NCI
anthraxpathway
Cellular roles of Anthrax toxin
il1pathway
IL1-mediated signaling events
p38gammadeltapathway
Signaling mediated by p38-gamma and p38-delta
vegfr1_2_pathway
Signaling events mediated by VEGFR1 and VEGFR2
p38alphabetapathway
Regulation of p38-alpha and p38-beta
ar_tf_pathway
Regulation of Androgen receptor activity
il6_7pathway
IL6-mediated signaling events
faspathway
FAS (CD95) signaling pathway
p38_mkk3_6pathway
p38 MAPK signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.561
RefSeq NM_001034045 XM_003585085 XM_005221340 XM_005221342
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca