InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Map2k6

Summary

InnateDB Gene

IDBG-213977.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Map2k6

Gene Name

mitogen-activated protein kinase kinase 6

Synonyms

MEK6; MKK6; Prkmk6; SAPKK3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020623

Encoded Proteins

IDBP-213979

mitogen-activated protein kinase kinase 6

IDBP-213981

mitogen-activated protein kinase kinase 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 9841871

[Homo sapiens] MAP2K6 activates MAPK14 (p38) MAP kinases.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000108984:
This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:110399122-110525522

Strand

Forward strand

Band

Transcripts

ENSMUST00000100260	ENSMUSP00000097831
ENSMUST00000020949	ENSMUSP00000020949
ENSMUST00000146084
ENSMUST00000146540
ENSMUST00000133920

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004702	receptor signaling protein serine/threonine kinase activity
GO:0004708	MAP kinase kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019901	protein kinase binding

Biological Process

GO:0000165	MAPK cascade
GO:0000187	activation of MAPK activity
GO:0001934	positive regulation of protein phosphorylation
GO:0002931	response to ischemia
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0006915	apoptotic process
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0022602	ovulation cycle process
GO:0032308	positive regulation of prostaglandin secretion
GO:0042493	response to drug
GO:0043065	positive regulation of apoptotic process
GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process
GO:0060048	cardiac muscle contraction
GO:0072709	cellular response to sorbitol