Version 5.4
Bos taurus Gene: ERBB4
Summary
InnateDB Gene IDBG-643612.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ERBB4
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000012647
Encoded Proteins
IDBP-696179
Uncharacterized protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000178568:
This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:99660620-99997642
Strand Reverse strand
Band
Transcripts
ENSBTAT00000061483 ENSBTAP00000053668
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 48 interaction(s) predicted by orthology.
Predicted by orthology
Total 48 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
Cellular Component
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000178568
View Gene Order
ENSMUSG00000062209
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_56
Prolactin pathway
REACTOME
REACT_239142
Innate Immune System pathway
REACT_198574
Nuclear signaling by ERBB4 pathway
REACT_188199
Signaling by the B Cell Receptor (BCR) pathway
REACT_188191
Signaling by ERBB2 pathway
REACT_205300
PI3K/AKT activation pathway
REACT_189085
Disease pathway
REACT_188177
Signaling by FGFR in disease pathway
REACT_188579
Signaling by ERBB4 pathway
REACT_188578
Signaling by SCF-KIT pathway
REACT_188574
SHC1 events in ERBB2 signaling pathway
REACT_226341
PIP3 activates AKT signaling pathway
REACT_230745
Immune System pathway
REACT_199100
Downregulation of ERBB4 signaling pathway
REACT_230639
Downstream signal transduction pathway
REACT_231729
Downstream signaling of activated FGFR pathway
REACT_196588
Constitutive PI3K/AKT Signaling in Cancer pathway
REACT_188580
SHC1 events in ERBB4 signaling pathway
REACT_203296
PI3K events in ERBB4 signaling pathway
REACT_223993
PI-3K cascade pathway
REACT_242976
Signaling by EGFR pathway
REACT_213364
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_188204
Fc epsilon receptor (FCERI) signaling pathway
REACT_226735
PI3K/AKT Signaling in Cancer pathway
REACT_248921
Signalling by NGF pathway
REACT_229531
Adaptive Immune System pathway
REACT_263353
Signaling by PDGF pathway
REACT_206286
GAB1 signalosome pathway
REACT_237883
NGF signalling via TRKA from the plasma membrane pathway
REACT_215348
PI3K events in ERBB2 signaling pathway
REACT_188257
Signal Transduction pathway
REACT_188528
GRB2 events in ERBB2 signaling pathway
REACT_242456
Signaling by FGFR pathway
REACT_188180
Signaling by EGFR in Cancer pathway
REACT_209507
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_188188
DAP12 interactions pathway
REACT_188185
DAP12 signaling pathway
KEGG
hsa04012
ErbB signaling pathway pathway
hsa04020
Calcium signaling pathway pathway
hsa04144
Endocytosis pathway
mmu04012
ErbB signaling pathway pathway
mmu04020
Calcium signaling pathway pathway
mmu04144
Endocytosis pathway
INOH
PID NCI
erbb4_pathway
ErbB4 signaling events
erbb_network_pathway
ErbB receptor signaling network
Cross-References
SwissProt
TrEMBL F1N758
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02005767 DAAA02005768 DAAA02005769 DAAA02005770 DAAA02005771 DAAA02005772 DAAA02005773 DAAA02005774
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca