Version 5.4
Bos taurus Gene: ARHGEF18
Summary
InnateDB Gene IDBG-643626.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARHGEF18
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000040507
Encoded Proteins
IDBP-696199
Rho/Rac guanine nucleotide exchange factor (GEF) 18
IDBP-696203
Rho/Rac guanine nucleotide exchange factor (GEF) 18
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000104880:
Rho GTPases are GTP binding proteins that regulate a wide spectrum of cellular functions. These cellular processes include cytoskeletal rearrangements, gene transcription, cell growth and motility. Activation of Rho GTPases is under the direct control of guanine nucleotide exchange factors (GEFs). The protein encoded by this gene is a guanine nucleotide exchange factor and belongs to the Rho GTPase GFE family. Family members share a common feature, a Dbl (DH) homology domain followed by a pleckstrin (PH) homology domain. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:17513881-17565624
Strand Forward strand
Band
Transcripts
ENSBTAT00000014311 ENSBTAP00000014311
ENSBTAT00000065966 ENSBTAP00000056421
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005089 Rho guanyl-nucleotide exchange factor activity
Biological Process
GO:0032321 positive regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
Cellular Component
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000104880
View Gene Order
ENSMUSG00000004568
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_13638
NRAGE signals death through JNK pathway
REACT_18407
G alpha (12/13) signalling events pathway
REACT_11051
Rho GTPase cycle pathway
REACT_120726
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) pathway
REACT_169107
SMAD4 MH2 Domain Mutants in Cancer pathway
REACT_11061
Signalling by NGF pathway
REACT_169219
Loss of Function of SMAD4 in Cancer pathway
REACT_169398
Loss of Function of SMAD2/3 in Cancer pathway
REACT_169122
Signaling by TGF-beta Receptor Complex in Cancer pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_14797
Signaling by GPCR pathway
REACT_13776
p75 NTR receptor-mediated signalling pathway
REACT_169192
TGFBR2 MSI Frameshift Mutants in Cancer pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_169165
SMAD2/3 MH2 Domain Mutants in Cancer pathway
REACT_169435
Loss of Function of TGFBR2 in Cancer pathway
REACT_169103
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
REACT_169263
TGFBR1 KD Mutants in Cancer pathway
REACT_13720
Cell death signalling via NRAGE, NRIF and NADE pathway
REACT_169311
Loss of Function of TGFBR1 in Cancer pathway
REACT_169445
TGFBR1 LBD Mutants in Cancer pathway
REACT_169440
TGFBR2 Kinase Domain Mutants in Cancer pathway
REACT_116125
Disease pathway
REACT_6844
Signaling by TGF-beta Receptor Complex pathway
REACT_217958
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
REACT_223625
GPCR downstream signaling pathway
REACT_189085
Disease pathway
REACT_254215
Signaling by GPCR pathway
REACT_215068
Loss of Function of SMAD4 in Cancer pathway
REACT_209641
NRAGE signals death through JNK pathway
REACT_213336
Signaling by TGF-beta Receptor Complex in Cancer pathway
REACT_224217
TGFBR1 LBD Mutants in Cancer pathway
REACT_204241
Loss of Function of TGFBR2 in Cancer pathway
REACT_206918
Signaling by Rho GTPases pathway
REACT_204413
Cell death signalling via NRAGE, NRIF and NADE pathway
REACT_204733
G alpha (12/13) signalling events pathway
REACT_196549
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) pathway
REACT_216792
SMAD2/3 MH2 Domain Mutants in Cancer pathway
REACT_224787
TGFBR2 Kinase Domain Mutants in Cancer pathway
REACT_210090
Rho GTPase cycle pathway
REACT_248921
Signalling by NGF pathway
REACT_223317
Loss of Function of TGFBR1 in Cancer pathway
REACT_209370
TGFBR2 MSI Frameshift Mutants in Cancer pathway
REACT_202264
SMAD4 MH2 Domain Mutants in Cancer pathway
REACT_188257
Signal Transduction pathway
REACT_224802
TGFBR1 KD Mutants in Cancer pathway
REACT_210847
p75 NTR receptor-mediated signalling pathway
REACT_225428
Signaling by TGF-beta Receptor Complex pathway
REACT_226256
Loss of Function of SMAD2/3 in Cancer pathway
KEGG
INOH
PID NCI
rhoa_reg_pathway
Regulation of RhoA activity
Cross-References
SwissProt
TrEMBL G3N3B9
UniProt Splice Variant
Entrez Gene
UniGene Bt.109942 Bt.111246
RefSeq
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02019498
GenPept
RNA Seq Atlas
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca