InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: GALNT1

Summary

InnateDB Gene

IDBG-643633.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GALNT1

Gene Name

Polypeptide N-acetylgalactosaminyltransferase 1 Polypeptide N-acetylgalactosaminyltransferase 1 soluble form

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000011206

Encoded Proteins

IDBP-696207

Polypeptide N-acetylgalactosaminyltransferase 1Polypeptide N-acetylgalactosaminyltransferase 1 soluble form

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000141429:
This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. Transcript variants derived from this gene that utilize alternative polyA signals have been described in the literature. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 24:21687846-21756844

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000014882

ENSBTAP00000014882

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity
GO:0016740	transferase activity
GO:0016757	transferase activity, transferring glycosyl groups
GO:0030145	manganese ion binding
GO:0046872	metal ion binding

Biological Process

GO:0006486	protein glycosylation
GO:0006493	protein O-linked glycosylation
GO:0018242	protein O-linked glycosylation via serine
GO:0018243	protein O-linked glycosylation via threonine

Cellular Component

GO:0005576	extracellular region
GO:0005794	Golgi apparatus
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0032580	Golgi cisterna membrane
GO:0048471	perinuclear region of cytoplasm