Version 5.4
Bos taurus Gene: SHARPIN
Summary
InnateDB Gene IDBG-643639.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SHARPIN
Gene Name Sharpin
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000012235
Encoded Proteins
IDBP-696209
Sharpin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 21709223
[Homo sapiens] SHARPIN is an essential adaptor downstream of IKBKG in the TLR signalling pathway. A mutation in the SHARPIN gene impairs IL12 production in TLR-stimulated macrophages.
PMID 22348129
[Homo sapiens] SHARPIN deficient dendritic cells show reduced inflammatory cytokine production, defective NF-kB signalling and skewing towards a Th2-response. (Demonstrated in mice)
PMID 21709223
[Mus musculus] Sharpin is an essential adaptor downstream of Ikbkg in the TLR signalling pathway. A mutation in the Sharpin gene impairs Il12 production in TLR-stimulated macrophages.
PMID 22348129
[Mus musculus] Sharpin deficient dendritic cells show reduced inflammatory cytokine production, defective NF-kB signalling and skewing towards a Th2-response.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000179526:
Gene Information
Type Protein coding
Genomic Location Chromosome 14:1925026-1929354
Strand Forward strand
Band
Transcripts
ENSBTAT00000049670 ENSBTAP00000046530
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 39 interaction(s) predicted by orthology.
Predicted by orthology
Total 39 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0031593 polyubiquitin binding
GO:0046872 metal ion binding
Biological Process
GO:0007005 mitochondrion organization
GO:0008544 epidermis development
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway
GO:0030262 apoptotic nuclear changes
GO:0031424 keratinization
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0050728 negative regulation of inflammatory response
GO:0097039 protein linear polyubiquitination
GO:2000348 regulation of CD40 signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0030054 cell junction
GO:0045202 synapse
GO:0071797 LUBAC complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000179526
View Gene Order
ENSMUSG00000022552
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.46353
RefSeq NM_001109766
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca