Version 5.4
Bos taurus Protein: SHARPIN
Summary
InnateDB Protein IDBP-696209.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SHARPIN
Protein Name Sharpin
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000046530
InnateDB Gene IDBG-643639 (SHARPIN)
Protein Structure
UniProt Annotation
Function Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytosol {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=Enriched at synaptic sites in mature neurons where it colocalizes with SHANK1. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 39 interaction(s) predicted by orthology.
Predicted by orthology
Total 39 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0031593 polyubiquitin binding
GO:0046872 metal ion binding
Biological Process
GO:0007005 mitochondrion organization
GO:0008544 epidermis development
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway
GO:0030262 apoptotic nuclear changes
GO:0031424 keratinization
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0050728 negative regulation of inflammatory response
GO:0097039 protein linear polyubiquitination
GO:2000348 regulation of CD40 signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0030054 cell junction
GO:0045202 synapse
GO:0071797 LUBAC complex
Protein Structure and Domains
PDB ID
InterPro IPR001876 Zinc finger, RanBP2-type
IPR029071 Ubiquitin-related domain
PFAM PF00641
PRINTS
PIRSF
SMART SM00547
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt E1BDF2
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 512499
UniGene Bt.46353
RefSeq NP_001103236
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AAFC03035445
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca