InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ATIC

Summary

InnateDB Gene

IDBG-643650.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATIC

Gene Name

Bifunctional purine biosynthesis protein PURH Phosphoribosylaminoimidazolecarboxamide formyltransferase IMP cyclohydrolase

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000019274

Encoded Proteins

IDBP-696222

Bifunctional purine biosynthesis protein PURHPhosphoribosylaminoimidazolecarboxamide formyltransferaseIMP cyclohydrolase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138363:
This gene encodes a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. The N-terminal domain has phosphoribosylaminoimidazolecarboxamide formyltransferase activity, and the C-terminal domain has IMP cyclohydrolase activity. A mutation in this gene results in AICA-ribosiduria. [provided by RefSeq, Sep 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:103847180-103870755

Strand

Forward strand

Band

Transcripts

ENSBTAT00000025662

ENSBTAP00000025662

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0003937	IMP cyclohydrolase activity
GO:0004643	phosphoribosylaminoimidazolecarboxamide formyltransferase activity
GO:0016740	transferase activity
GO:0016787	hydrolase activity
GO:0042803	protein homodimerization activity