InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Atic

Summary

InnateDB Gene

IDBG-164930.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atic

Gene Name

5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase

Synonyms

2610509C24Rik; AA536954; AW212393

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026192

Encoded Proteins

IDBP-164932

5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138363:
This gene encodes a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. The N-terminal domain has phosphoribosylaminoimidazolecarboxamide formyltransferase activity, and the C-terminal domain has IMP cyclohydrolase activity. A mutation in this gene results in AICA-ribosiduria. [provided by RefSeq, Sep 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:71557150-71579631

Strand

Forward strand

Band

Transcripts

ENSMUST00000027384	ENSMUSP00000027384
ENSMUST00000148077
ENSMUST00000155769
ENSMUST00000136443
ENSMUST00000154855
ENSMUST00000187982

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0003937	IMP cyclohydrolase activity
GO:0004643	phosphoribosylaminoimidazolecarboxamide formyltransferase activity
GO:0042803	protein homodimerization activity

Biological Process

GO:0003360	brainstem development
GO:0006164	purine nucleotide biosynthetic process
GO:0006189	'de novo' IMP biosynthetic process
GO:0009116	nucleoside metabolic process
GO:0009259	ribonucleotide metabolic process
GO:0010035	response to inorganic substance
GO:0021549	cerebellum development
GO:0021987	cerebral cortex development
GO:0031100	organ regeneration
GO:0046452	dihydrofolate metabolic process
GO:0046654	tetrahydrofolate biosynthetic process