Version 5.4
Bos taurus Gene: PNPLA6
Summary
InnateDB Gene IDBG-643651.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PNPLA6
Gene Name neuropathy target esterase
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000032137
Encoded Proteins
IDBP-696229
neuropathy target esterase
IDBP-696232
neuropathy target esterase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000032444:
This gene encodes a phospholipase that deacetylates intracellular phosphatidylcholine to produce glycerophosphocholine. It is thought to function in neurite outgrowth and process elongation during neuronal differentiation. The protein is anchored to the cytoplasmic face of the endoplasmic reticulum in both neurons and non-neuronal cells. Mutations in this gene result in autosomal recessive spastic paraplegia, and the protein is the target for neurodegeneration induced by organophosphorus compounds and chemical warfare agents. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:17624452-17647840
Strand Forward strand
Band
Transcripts
ENSBTAT00000007351 ENSBTAP00000007351
ENSBTAT00000032631 ENSBTAP00000032560
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004622 lysophospholipase activity
Biological Process
GO:0001525 angiogenesis
GO:0006629 lipid metabolic process
GO:0008152 metabolic process
GO:0009887 organ morphogenesis
GO:0046470 phosphatidylcholine metabolic process
Cellular Component
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000032444
View Gene Order
ENSMUSG00000004565
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00564
Glycerophospholipid metabolism pathway
mmu00564
Glycerophospholipid metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F1MJZ8
UniProt Splice Variant
Entrez Gene 767822
UniGene
RefSeq
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02019500 DAAA02019501
GenPept
RNA Seq Atlas 767822

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca