Version 5.4
Bos taurus Gene: FN1
Summary
InnateDB Gene IDBG-643655.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FN1
Gene Name fibronectin precursor
Synonyms FN
Species Bos taurus
Ensembl Gene ENSBTAG00000008300
Encoded Proteins
IDBP-696249
fibronectin
IDBP-696251
fibronectin
IDBP-696252
fibronectin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115414:
This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants. However, the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:103881402-103950562
Strand Reverse strand
Band
Transcripts
ENSBTAT00000010925 ENSBTAP00000010925
ENSBTAT00000010922 ENSBTAP00000010922
ENSBTAT00000010926 ENSBTAP00000010926
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 605 interaction(s) predicted by orthology.
Predicted by orthology
Total 605 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002020 protease binding
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0016504 peptidase activator activity
Biological Process
GO:0007044 cell-substrate junction assembly
GO:0007155 cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007161 calcium-independent cell-matrix adhesion
GO:0010952 positive regulation of peptidase activity
GO:0018149 peptide cross-linking
GO:0034446 substrate adhesion-dependent cell spreading
GO:0042060 wound healing
GO:0045773 positive regulation of axon extension
Cellular Component
GO:0005576 extracellular region
GO:0005577 fibrinogen complex
GO:0005604 basement membrane
GO:0005605 basal lamina
GO:0005615 extracellular space
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0016324 apical plasma membrane
GO:0031012 extracellular matrix
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000115414
View Gene Order
ENSMUSG00000026193
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_15443
GRB2:SOS provides linkage to MAPK signaling for Integrins pathway
REACT_15381
p130Cas linkage to MAPK signaling for integrins pathway
REACT_15523
Integrin alphaIIb beta3 signaling pathway
REACT_278
Platelet Aggregation (Plug Formation) pathway
REACT_318
Platelet degranulation pathway
REACT_1280
Response to elevated platelet cytosolic Ca2+ pathway
REACT_13552
Integrin cell surface interactions pathway
REACT_150331
Molecules associated with elastic fibres pathway
REACT_150366
Elastic fibre formation pathway
REACT_160131
Fibronectin matrix formation pathway
REACT_118779
Extracellular matrix organization pathway
REACT_118572
Degradation of the extracellular matrix pathway
REACT_163942
Syndecan interactions pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_111102
Signal Transduction pathway
REACT_163906
ECM proteoglycans pathway
REACT_163874
Non-integrin membrane-ECM interactions pathway
REACT_604
Hemostasis pathway
REACT_230203
Platelet degranulation pathway
REACT_196644
Syndecan interactions pathway
REACT_224553
Hemostasis pathway
REACT_204211
Fibronectin matrix formation pathway
REACT_198996
Elastic fibre formation pathway
REACT_198998
Molecules associated with elastic fibres pathway
REACT_225233
Cell surface interactions at the vascular wall pathway
REACT_206066
Extracellular matrix organization pathway
REACT_224879
Platelet activation, signaling and aggregation pathway
REACT_216309
Integrin cell surface interactions pathway
REACT_238268
GRB2:SOS provides linkage to MAPK signaling for Integrins pathway
REACT_196606
ECM proteoglycans pathway
REACT_196607
Non-integrin membrane-ECM interactions pathway
REACT_240371
p130Cas linkage to MAPK signaling for integrins pathway
REACT_206166
Response to elevated platelet cytosolic Ca2+ pathway
REACT_188257
Signal Transduction pathway
REACT_246176
Integrin alphaIIb beta3 signaling pathway
REACT_249309
Platelet Aggregation (Plug Formation) pathway
REACT_199052
Degradation of the extracellular matrix pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04512
ECM-receptor interaction pathway
hsa05222
Small cell lung cancer pathway
hsa04510
Focal adhesion pathway
hsa05200
Pathways in cancer pathway
hsa05146
Amoebiasis pathway
hsa05100
Bacterial invasion of epithelial cells pathway
mmu04512
ECM-receptor interaction pathway
mmu04810
Regulation of actin cytoskeleton pathway
mmu05222
Small cell lung cancer pathway
mmu04510
Focal adhesion pathway
mmu05200
Pathways in cancer pathway
mmu05146
Amoebiasis pathway
mmu05100
Bacterial invasion of epithelial cells pathway
INOH
INOH website
Integrin signaling pathway pathway
INOH website
Integrin signaling pathway pathway
PID NCI
syndecan_2_pathway
Syndecan-2-mediated signaling events
integrin1_pathway
Beta1 integrin cell surface interactions
avb3_integrin_pathway
Integrins in angiogenesis
lymphangiogenesis_pathway
VEGFR3 signaling in lymphatic endothelium
upa_upar_pathway
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
integrin_a9b1_pathway
Alpha9 beta1 integrin signaling events
angiopoietinreceptor_pathway
Angiopoietin receptor Tie2-mediated signaling
syndecan_4_pathway
Syndecan-4-mediated signaling events
integrin_a4b1_pathway
Alpha4 beta1 integrin signaling events
integrin3_pathway
Beta3 integrin cell surface interactions
integrin5_pathway
Beta5 beta6 beta7 and beta8 integrin cell surface interactions
Cross-References
SwissProt
TrEMBL A1XEA1 B8Y9S9 Q71U44 Q862C9 Q865Z7 Q9MZ31
UniProt Splice Variant
Entrez Gene 280794
UniGene Bt.23418
RefSeq NM_001163778 XM_005202777 XM_005202784
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AB099071 AF136453 AF260305 AY221633 DAAA02005870 DQ347566 FJ513187
GenPept AAD33692 AAF91381 AAO72631 ABC55275 ACL77782 BAC56561
RNA Seq Atlas 280794

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca