Version 5.4
Bos taurus Gene: BT.20299
Summary
InnateDB Gene IDBG-643677.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.20299
Gene Name syntaxin-binding protein 2
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000009178
Encoded Proteins
IDBP-696258
syntaxin-binding protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000076944:
This gene encodes a member of the STXBP/unc-18/SEC1 family. The encoded protein is involved in intracellular trafficking, control of SNARE (soluble NSF attachment protein receptor) complex assembly, and the release of cytotoxic granules by natural killer cells. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:17706870-17715987
Strand Forward strand
Band
Transcripts
ENSBTAT00000012094 ENSBTAP00000012094
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0017075 syntaxin-1 binding
GO:0030348 syntaxin-3 binding
Biological Process
GO:0001909 leukocyte mediated cytotoxicity
GO:0006887 exocytosis
GO:0006904 vesicle docking involved in exocytosis
GO:0016192 vesicle-mediated transport
GO:0043312 neutrophil degranulation
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016324 apical plasma membrane
GO:0031201 SNARE complex
GO:0042581 specific granule
GO:0042582 azurophil granule
GO:0044194 cytolytic granule
GO:0070062 extracellular vesicular exosome
GO:0070820 tertiary granule
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000076944
View Gene Order
ENSMUSG00000004626
View Gene Order
Cross-References
SwissProt
TrEMBL F1MHC2
UniProt Splice Variant
Entrez Gene 515618
UniGene Bt.20299
RefSeq NM_001046208 XM_005208746 XM_005208747
HUGO HGNC:11445
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02019501 DAAA02019502
GenPept
RNA Seq Atlas 515618

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca