Version 5.4
Bos taurus Gene: SMARCAL1
Summary
InnateDB Gene IDBG-643727.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SMARCAL1
Gene Name SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000003843
Encoded Proteins
IDBP-696310
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138375:
The protein encoded by this gene is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein shows sequence similarity to the E. coli RNA polymerase-binding protein HepA. Mutations in this gene are a cause of Schimke immunoosseous dysplasia (SIOD), an autosomal recessive disorder with the diagnostic features of spondyloepiphyseal dysplasia, renal dysfunction, and T-cell immunodeficiency. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:105138334-105188478
Strand Forward strand
Band
Transcripts
ENSBTAT00000005013 ENSBTAP00000005013
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008094 DNA-dependent ATPase activity
GO:0016787 hydrolase activity
GO:0036310 annealing helicase activity
Biological Process
GO:0000733 DNA strand renaturation
GO:0006200 ATP catabolic process
GO:0006259 DNA metabolic process
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006974 cellular response to DNA damage stimulus
GO:0016568 chromatin modification
GO:0031297 replication fork processing
Cellular Component
GO:0005634 nucleus
GO:0005662 DNA replication factor A complex
GO:0035861 site of double-strand break
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000138375
View Gene Order
ENSMUSG00000039354
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
atr_pathway
ATR signaling pathway
Cross-References
SwissProt Q9TTA5
TrEMBL
UniProt Splice Variant
Entrez Gene 338072
UniGene
RefSeq NM_176666 XM_005202807 XM_005202808
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF173643 DAAA02005900
GenPept AAF22285
RNA Seq Atlas 338072

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca