InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PDE6B

Summary

InnateDB Gene

IDBG-643770.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDE6B

Gene Name

Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000017480

Encoded Proteins

IDBP-696352

phosphodiesterase 6B, cGMP-specific, rod, beta

IDBP-696356

phosphodiesterase 6B, cGMP-specific, rod, beta

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000133256:
Photon absorption triggers a signaling cascade in rod photoreceptors that activates cGMP phosphodiesterase (PDE), resulting in the rapid hydrolysis of cGMP, closure of cGMP-gated cation channels, and hyperpolarization of the cell. PDE is a peripheral membrane heterotrimeric enzyme made up of alpha, beta, and gamma subunits. This gene encodes the beta subunit. Mutations in this gene result in retinitis pigmentosa and autosomal dominant congenital stationary night blindness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:108818344-108849344

Strand

Forward strand

Band

Transcripts

ENSBTAT00000052174	ENSBTAP00000052098
ENSBTAT00000023239	ENSBTAP00000023239

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0005515	protein binding
GO:0008081	phosphoric diester hydrolase activity
GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity

Biological Process

GO:0007165	signal transduction
GO:0008152	metabolic process
GO:0009583	detection of light stimulus
GO:0046037	GMP metabolic process
GO:0051480	cytosolic calcium ion homeostasis
GO:0060041	retina development in camera-type eye