Mus musculus Gene: Pde6b | |||||||||||||
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Summary | |||||||||||||
InnateDB Gene | IDBG-187888.6 | ||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||
Gene Symbol | Pde6b | ||||||||||||
Gene Name | phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide | ||||||||||||
Synonyms | Pdeb; r; rd; rd-1; rd1; rd10 | ||||||||||||
Species | Mus musculus | ||||||||||||
Ensembl Gene | ENSMUSG00000029491 | ||||||||||||
Encoded Proteins |
phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide
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Protein Structure | |||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||
Entrez Gene | |||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000133256:
Photon absorption triggers a signaling cascade in rod photoreceptors that activates cGMP phosphodiesterase (PDE), resulting in the rapid hydrolysis of cGMP, closure of cGMP-gated cation channels, and hyperpolarization of the cell. PDE is a peripheral membrane heterotrimeric enzyme made up of alpha, beta, and gamma subunits. This gene encodes the beta subunit. Mutations in this gene result in retinitis pigmentosa and autosomal dominant congenital stationary night blindness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009] |
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Gene Information | |||||||||||||
Type | Protein coding | ||||||||||||
Genomic Location | Chromosome 5:108388391-108432397 | ||||||||||||
Strand | Forward strand | ||||||||||||
Band | F | ||||||||||||
Transcripts |
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Interactions | |||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||
NETPATH | |||||||||||||
REACTOME |
Disease pathway
Signaling by Wnt pathway
beta-catenin independent WNT signaling pathway
Ca2+ pathway pathway
Visual phototransduction pathway
Inactivation, recovery and regulation of the phototransduction cascade pathway
The phototransduction cascade pathway
Signal Transduction pathway
Diseases associated with visual transduction pathway
Activation of the phototransduction cascade pathway
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KEGG |
Purine metabolism pathway
Phototransduction pathway
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INOH | |||||||||||||
PID NCI | |||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||
NETPATH | |||||||||||||
REACTOME |
Ca2+ pathway pathway
Activation of the phototransduction cascade pathway
beta-catenin independent WNT signaling pathway
Signaling by Wnt pathway
Signal Transduction pathway
Diseases associated with visual transduction pathway
Visual phototransduction pathway
The phototransduction cascade pathway
Inactivation, recovery and regulation of the phototransduction cascade pathway
Disease pathway
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KEGG |
Purine metabolism pathway
Phototransduction pathway
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INOH |
Purine nucleotides nucleosides metabolism pathway
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PID NCI |
Visual signal transduction: Rods
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Cross-References | |||||||||||||
SwissProt | P23440 | ||||||||||||
TrEMBL | Q6P6H9 Q8CA78 | ||||||||||||
UniProt Splice Variant | |||||||||||||
Entrez Gene | 18587 | ||||||||||||
UniGene | Mm.1372 | ||||||||||||
RefSeq | NM_008806 | ||||||||||||
OMIM | |||||||||||||
CCDS | CCDS19510 | ||||||||||||
HPRD | |||||||||||||
IMGT | |||||||||||||
MGI ID | MGI:97525 | ||||||||||||
MGI Symbol | Pde6b | ||||||||||||
EMBL | AK039397 AK044364 BC062209 CH466529 X55968 X60133 | ||||||||||||
GenPept | AAH62209 BAC30338 BAC31885 CAA39439 CAA42719 EDL20122 | ||||||||||||
RNA Seq Atlas | 18587 | ||||||||||||