Version 5.4
| Bos taurus Gene: GPBAR1 | |||||||||
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| Summary | |||||||||
| InnateDB Gene | IDBG-643789.3 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | GPBAR1 | ||||||||
| Gene Name | G-protein coupled bile acid receptor 1 | ||||||||
| Synonyms | TGR5 | ||||||||
| Species | Bos taurus | ||||||||
| Ensembl Gene | ENSBTAG00000003923 | ||||||||
| Encoded Proteins |
G-protein coupled bile acid receptor 1
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| Entrez Gene | |||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000179921:
This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome 2:107011785-107014997 | ||||||||
| Strand | Forward strand | ||||||||
| Band | |||||||||
| Transcripts |
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| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathways | |||||||||
| NETPATH | |||||||||
| REACTOME |
Signaling by GPCR pathway
G alpha (s) signalling events pathway
Signal Transduction pathway
GPCR downstream signaling pathway
GPCR ligand binding pathway
Class A/1 (Rhodopsin-like receptors) pathway
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| KEGG | |||||||||
| INOH | |||||||||
| PID NCI | |||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||
| NETPATH | |||||||||
| REACTOME |
G alpha (s) signalling events pathway
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Signal Transduction pathway
GPCR downstream signaling pathway
GPCR ligand binding pathway
G alpha (s) signalling events pathway
GPCR downstream signaling pathway
Signaling by GPCR pathway
Class A/1 (Rhodopsin-like receptors) pathway
GPCR ligand binding pathway
Signal Transduction pathway
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| KEGG | |||||||||
| INOH | |||||||||
| PID NCI | |||||||||
| Cross-References | |||||||||
| SwissProt | Q862A9 | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 317756 | ||||||||
| UniGene | Bt.65225 | ||||||||
| RefSeq | NM_175049 XM_005202806 | ||||||||
| HUGO | |||||||||
| OMIM | |||||||||
| CCDS | |||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AB089306 BC122824 | ||||||||
| GenPept | AAI22825 BAC55234 | ||||||||
| RNA Seq Atlas | 317756 | ||||||||