InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PTP4A3

Summary

InnateDB Gene

IDBG-643907.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTP4A3

Gene Name

Protein tyrosine phosphatase type IVA 3

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000046467

Encoded Proteins

IDBP-696505

Protein tyrosine phosphatase type IVA 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000184489:
The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs). PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. This class of PTPs contain a PTP domain and a characteristic C-terminal prenylation motif. Studies of this class of PTPs in mice demonstrated that they were prenylated proteins in vivo, which suggested their association with cell plasma membrane. Overexpression of this gene in mammalian cells was reported to inhibit angiotensin-II induced cell calcium mobilization and promote cell growth. Two alternatively spliced variants exist. [provided by RefSeq, Jul 2008]
This gene encodes a member of the protein-tyrosine phosphatase family. Protein tyrosine phosphatases are cell signaling molecules that play regulatory roles in a variety of cellular processes. Studies of this class of protein tyrosine phosphatase in mice demonstrates that they are prenylated in vivo, suggesting their association with cell plasma membrane. The encoded protein may enhance cell proliferation, and overexpression of this gene has been implicated in tumor metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:3578346-3586015

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000064455

ENSBTAP00000056281

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 94 interaction(s) predicted by orthology.

Predicted by orthology
Total	94 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004721	phosphoprotein phosphatase activity
GO:0004725	protein tyrosine phosphatase activity
GO:0008138	protein tyrosine/serine/threonine phosphatase activity
GO:0016787	hydrolase activity
GO:0016791	phosphatase activity

Biological Process

GO:0006470	protein dephosphorylation
GO:0016311	dephosphorylation
GO:0035335	peptidyl-tyrosine dephosphorylation

Cellular Component

GO:0005768	endosome
GO:0005769	early endosome
GO:0005886	plasma membrane
GO:0016020	membrane

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000184489

View Gene Order

ENSMUSG00000059895

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

prlsignalingeventspathway

Signaling events mediated by PRL

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Bt.101302

RefSeq

NM_001083766 XM_005215123 XM_005215124

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas

Transcript Frequencies

Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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