Version 5.4
| Homo sapiens Gene: PTP4A3 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-37455.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | PTP4A3 | ||||||||||||||||||
| Gene Name | protein tyrosine phosphatase type IVA, member 3 | ||||||||||||||||||
| Synonyms | PRL-3; PRL-R; PRL3 | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000184489 | ||||||||||||||||||
| Encoded Proteins |
protein tyrosine phosphatase type IVA, member 3
protein tyrosine phosphatase type IVA, member 3
protein tyrosine phosphatase type IVA, member 3
protein tyrosine phosphatase type IVA, member 3
protein tyrosine phosphatase type IVA, member 3
protein tyrosine phosphatase type IVA, member 3
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs). PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. This class of PTPs contain a PTP domain and a characteristic C-terminal prenylation motif. Studies of this class of PTPs in mice demonstrated that they were prenylated proteins in vivo, which suggested their association with cell plasma membrane. Overexpression of this gene in mammalian cells was reported to inhibit angiotensin-II induced cell calcium mobilization and promote cell growth. Two alternatively spliced variants exist. [provided by RefSeq, Jul 2008] This gene encodes a member of the protein-tyrosine phosphatase family. Protein tyrosine phosphatases are cell signaling molecules that play regulatory roles in a variety of cellular processes. Studies of this class of protein tyrosine phosphatase in mice demonstrates that they are prenylated in vivo, suggesting their association with cell plasma membrane. The encoded protein may enhance cell proliferation, and overexpression of this gene has been implicated in tumor metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 8:141391993-141432454 | ||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||
| Band | q24.3 | ||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME | |||||||||||||||||||
| KEGG | |||||||||||||||||||
| INOH | |||||||||||||||||||
| PID NCI |
Signaling events mediated by PRL
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| Cross-References | |||||||||||||||||||
| SwissProt | O75365 | ||||||||||||||||||
| TrEMBL | E5RGR3 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 11156 | ||||||||||||||||||
| UniGene | |||||||||||||||||||
| RefSeq | NM_007079 NM_032611 XM_005250762 XM_005250763 XM_005250764 XM_005250767 XM_006716499 XM_006725100 XM_006725101 XM_006725102 XM_006725103 | ||||||||||||||||||
| HUGO | HGNC:9636 | ||||||||||||||||||
| OMIM | 606449 | ||||||||||||||||||
| CCDS | CCDS6383 CCDS6382 | ||||||||||||||||||
| HPRD | 05922 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AC100803 AF041434 AJ276554 BC003105 BT007303 U87168 | ||||||||||||||||||
| GenPept | AAB47560 AAC29314 AAH03105 AAP35967 CAC81757 | ||||||||||||||||||
| RNA Seq Atlas | 11156 | ||||||||||||||||||