Version 5.4
Bos taurus Gene: NHEJ1
Summary
InnateDB Gene IDBG-643928.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NHEJ1
Gene Name non-homologous end-joining factor 1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000031041
Encoded Proteins
IDBP-696528
non-homologous end-joining factor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000187736:
Double-strand breaks in DNA result from genotoxic stresses and are among the most damaging of DNA lesions. This gene encodes a DNA repair factor essential for the nonhomologous end-joining pathway, which preferentially mediates repair of double-stranded breaks. Mutations in this gene cause different kinds of severe combined immunodeficiency disorders. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:107742904-107834901
Strand Reverse strand
Band
Transcripts
ENSBTAT00000043942 ENSBTAP00000041475
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
Biological Process
GO:0006281 DNA repair
GO:0006302 double-strand break repair
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0006310 DNA recombination
GO:0010212 response to ionizing radiation
GO:0030183 B cell differentiation
GO:0030217 T cell differentiation
Cellular Component
GO:0005634 nucleus
GO:0070419 nonhomologous end joining complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000187736
View Gene Order
ENSMUSG00000026162
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa03450
Non-homologous end-joining pathway
mmu03450
Non-homologous end-joining pathway
INOH
PID NCI
dnapk_pathway
DNA-PK pathway in nonhomologous end joining
Cross-References
SwissProt
TrEMBL Q1JQA6
UniProt Splice Variant
Entrez Gene 509157
UniGene Bt.26602
RefSeq NM_001075393
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC116103 DAAA02005942 DAAA02005943
GenPept AAI16104
RNA Seq Atlas 509157

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca