Version 5.4
Mus musculus Gene: Nhej1
Summary
InnateDB Gene IDBG-169106.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nhej1
Gene Name nonhomologous end-joining factor 1
Synonyms 1700029B21Rik; cernunnos; XLF
Species Mus musculus
Ensembl Gene ENSMUSG00000026162
Encoded Proteins
IDBP-536323
nonhomologous end-joining factor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000187736:
Double-strand breaks in DNA result from genotoxic stresses and are among the most damaging of DNA lesions. This gene encodes a DNA repair factor essential for the nonhomologous end-joining pathway, which preferentially mediates repair of double-stranded breaks. Mutations in this gene cause different kinds of severe combined immunodeficiency disorders. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:74967139-75125200
Strand Reverse strand
Band C4
Transcripts
ENSMUST00000152855 ENSMUSP00000116797
ENSMUST00000188033
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
Biological Process
GO:0006281 DNA repair
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0006310 DNA recombination
GO:0010212 response to ionizing radiation
GO:0030183 B cell differentiation
GO:0030217 T cell differentiation
Cellular Component
GO:0005634 nucleus
GO:0070419 nonhomologous end joining complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000187736
View Gene Order
ENSBTAG00000031041
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu03450
Non-homologous end-joining pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa03450
Non-homologous end-joining pathway
INOH
PID NCI
dnapk_pathway
DNA-PK pathway in nonhomologous end joining
Cross-References
SwissProt Q3KNJ2
TrEMBL F7BTP0
UniProt Splice Variant
Entrez Gene 75570
UniGene Mm.442409
RefSeq NM_029342
OMIM
CCDS
HPRD
IMGT
MGI ID MGI:1922820
MGI Symbol Nhej1
EMBL AC104542 AC139023 AK006481 BC006063 BC107252 BC107253 BC132359 BC132361
GenPept AAH06063 AAI07253 AAI07254 AAI32360 AAI32362 BAB24611
RNA Seq Atlas 75570

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca